Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CCNH | P51946 | 1/20 | 0.36 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.35 |
| ▸ | FLT3 | P36888 | 3/20 | 0.35 |
| ▸ | AXL | P30530 | 2/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4269127 | 0.87 | CSNK2A2 (0.43) | GPR119CHEK1CHEK2CDK2CDK6 | |
| SCHEMBL391902 | 0.81 | GPR119 (0.51) | GPR119TBK1IKBKE | |
| SCHEMBL4721855 | 0.80 | GPR119 (0.41) | GPR119CDK2CDK6CCNT1CCNA2 | |
| SCHEMBL5049760 | 0.80 | GPR119 (0.43) | GPR119CDK2CDK6CSNK2A2CSNK2A1 | |
| SCHEMBL5046883 | 0.79 | GPR119 (0.39) | GPR119CHEK1CHEK2CDK2CDK6 | |
| SCHEMBL27747809 | 0.77 | GPR119 (0.39) | GPR119CDK2CDK6CCNT1CCNA2 | |
| SCHEMBL5264798 | 0.76 | GPR119 (0.41) | GPR119CDK2CDK6CCNT1CCNA2 | |
| SCHEMBL5048550 | 0.74 | GPR119 (0.49) | GPR119CDK2CDK6CCNT1CCNA2 | |
| SCHEMBL5046882 | 0.73 | GPR119 (0.46) | GPR119CDK2CDK6CCNT1CCNA2 | |
| SCHEMBL5190352 | 0.71 | GPR119 (0.49) | GPR119CDK2CDK6CCNT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004157-A2 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AS WELL AS COMBINATION THERAPY RELATING THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007120702-A2 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AND COMBINATION THERAPY RELATING THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |