Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | THPO | P40225 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | GNPAT | O15228 | 2/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 5/20 | 0.42 |
| ▸ | NAALAD2 | Q9Y3Q0 | 3/20 | 0.42 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.42 |
| ▸ | ALB | P02768 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL468750 | 0.98 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTKDM4ETHRBALOX15 | |
| SCHEMBL468749 | 0.98 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTKDM4ETHRBALOX15 | |
| Hydrogen Sulfide SCHEMBL27584727 | 0.96 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTKDM4ETHRBALOX15 | |
| Methane SCHEMBL5044798 | 0.96 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTKDM4ETHRBALOX15 | |
| Methane SCHEMBL5044803 | 0.96 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTKDM4ETHRBALOX15 | |
| SCHEMBL6841658 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTKDM4ETHRBALOX15 | |
| SCHEMBL6896498 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTKDM4ETHRBALOX15 | |
| SCHEMBL19183299 | 0.82 | KDM4E (0.45) | SMN1; SMN2MAPTKDM4ETHRBALOX15 | |
| SCHEMBL16745724 | 0.82 | GNPAT (0.62) | SMN1; SMN2MAPTKDM4ETHRBALOX15 | |
| SCHEMBL7719184 | 0.82 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPTKDM4ETHRBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103397057-B | Produce the microorganism of L-Methionine precursor and prepare L-Methionine and organic acid method by L-Methionine precursor | CJ CHEILJEDANG CORP. (KR) | 2016-03-23 | — | — | CN | disclosed |
| CN-101356281-B | Microorganism producing L-methionine precursor and method for producing L-methionine and organic acid from L-methionine precursor | CJ CHEILJEDANG CORP. (KR) | 2015-08-19 | — | — | CN | disclosed |
| CN-102943096-B | Microorganism producing l-methionine precursor and method of producing l-methionine and organic acid from the l-methionine precursor | CJ CHEILJEDANG CORP | 2014-08-27 | — | — | CN | disclosed |
| CN-103397057-A | Microorganism producing L-methionine precursor and method of producing L-methionine and organic acid from L-methionine precursor | CJ CHEILJEDANG CORP | 2013-11-20 | — | — | CN | disclosed |
| CN-102943096-A | Microorganism producing l-methionine precursor and method of producing l-methionine and organic acid from the l-methionine precursor | CJ CHEILJEDANG CORP | 2013-02-27 | — | — | CN | disclosed |
| CN-101356281-A | Microorganism producing L-methionine precursor and method for producing L-methionine and organic acid from L-methionine precursor | CJ CORP (KR) | 2009-01-28 | — | — | CN | disclosed |