Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2771401 | 0.89 | PTGDR2 (0.50) | PTGDR2PTGS2KCNQ3KCNQ2CYP2C9 | |
| SCHEMBL2768834 | 0.88 | L3MBTL1 (0.43) | PTGDR2PTGS2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2770081 | 0.86 | PTGDR2 (0.46) | PTGDR2POLBPTGS2PTGS1ALDH1A1 | |
| SCHEMBL27714352 | 0.85 | PTGDR2 (0.35) | PTGDR2PTGS2KCNQ3KCNQ2CYP1A2 | |
| SCHEMBL2772075 | 0.84 | PTGDR2 (0.38) | PTGDR2PTGS2PTGS1ALDH1A1CYP2C9 | |
| SCHEMBL4635946 | 0.84 | L3MBTL1 (0.40) | PTGDR2POLBPTGS2PTGS1ALDH1A1 | |
| SCHEMBL2770749 | 0.83 | PTGDR2 (0.42) | PTGDR2PTGS2PTGS1 | |
| SCHEMBL2769682 | 0.83 | L3MBTL1 (0.41) | PTGDR2PTGS2PTGS1ALDH1A1CYP1A2 | |
| SCHEMBL3568010 | 0.80 | PTGDR2 (0.47) | PTGDR2PTGS2PTGS1ALDH1A1 | |
| SCHEMBL27714354 | 0.78 | PTGS2 (0.33) | PTGDR2PTGS2PTGS1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910357-B1 | INDOLI ZINE DERIVATIVES AND THEIR USE AS CRTH2 ANTAGONISTS | ARGENTA DISCOVERY LTD (GB) | 2010-04-14 | — | — | EP | disclosed |
| US-20090163534-A1 | Indolizine Derivatives | ARGENTA DISCOVERY LIMITED (GB) | 2009-06-25 | — | — | US | disclosed |
| EP-1910357-A2 | INDOLI ZINE DERIVATIVES AND THEIR USE AS CRTH2 ANTAGONISTS | Argenta Discovery Limited (GB) | 2008-04-16 | — | — | EP | disclosed |
| WO-2006136859-A2 | INDOLI ZINE DERIVATIVES AND THEIR USE AS CRTH2 ANTAGONISTS | ARGENTA DISCOVERY LIMITED (GB) | 2006-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163534-A1 | Indolizine Derivatives | HRH4, HRH2, NR1H2 | PTGDR2 363/4885POLB 4250/4885PTGS2 2243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.