Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 4/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL516558 | 0.87 | HTT (0.57) | HTTLMNAMAPTALDH1A1HPGD | |
| SCHEMBL1224946 | 0.74 | HTT (0.44) | HTTLMNAMAPTALDH1A1HPGD | |
| SCHEMBL30665799 | 0.70 | HTT (0.57) | HTTLMNAMAPTALDH1A1HPGD | |
| SCHEMBL3521038 | 0.70 | HTT (0.58) | HTTLMNAMAPTALDH1A1HPGD | |
| SCHEMBL3458498 | 0.70 | HTT (0.57) | HTTLMNAMAPTALDH1A1HPGD | |
| SCHEMBL11127797 | 0.69 | HTT (0.53) | HTTLMNAMAPTALDH1A1HPGD | |
| Benzenesulfonamide SCHEMBL28331799 | 0.69 | CA2 (0.70) | MAPTCA12CA1CA2CA9 | |
| Quinoxaline SCHEMBL27468711 | 0.68 | ALDH1A1 (0.41) | MAPTALDH1A1KMT2APOLBPDE10A | |
| SCHEMBL27914649 | 0.68 | HTT (0.56) | HTTLMNAMAPTALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL28203639 | 0.68 | HTT (0.56) | HTTLMNAMAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101296909-B | pyrazine derivatives and application thereof as PI3K inhibitor | SERONO LAB | 2011-10-12 | — | — | CN | disclosed |
| CN-101296909-A | Pyrazine derivatives and application thereof as PI3K inhibitor | SERONO LAB (CH) | 2008-10-29 | — | — | CN | disclosed |