Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | CPB1 | P15086 | 3/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.36 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27648842 | 0.82 | CYP1A2 (0.37) | PDE3BPDE3ACPB1CPB2CYP1A2 | |
| SCHEMBL4433834 | 0.81 | CPB2 (0.50) | PDE3BPDE3ACPB1CPB2PDE10A | |
| SCHEMBL4432563 | 0.79 | NOTUM (0.51) | PDE3BPDE3ACPB1CPB2KDM4E | |
| SCHEMBL3426575 | 0.79 | PDE3B (0.50) | PDE3BPDE3ACPB1CPB2SCD | |
| SCHEMBL2173293 | 0.79 | PDE3B (0.50) | PDE3BPDE3ACPB1CPB2SCD | |
| SCHEMBL4434213 | 0.79 | NOTUM (0.51) | PDE3BPDE3ACPB1CPB2KDM4E | |
| SCHEMBL4428918 | 0.79 | PDE3B (0.53) | PDE3BPDE3ACPB1CPB2SCD | |
| SCHEMBL4427934 | 0.76 | PDE3B (0.54) | PDE3BPDE3ACPB1CPB2PDE10A | |
| SCHEMBL6785441 | 0.75 | NOTUM (0.55) | PDE3BPDE3ACPB1CPB2NOTUM | |
| SCHEMBL4425521 | 0.75 | P2RX7 (0.55) | PDE3BPDE3ACPB1CPB2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101490036-B | Factor xa inhibitors | MILLENNIUM PHARM INC | 2013-07-17 | — | — | CN | disclosed |
| CN-101490036-A | Factor XA inhibitors | MILLENNIUM PHARM INC (US) | 2009-07-22 | — | — | CN | disclosed |