Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CHKA | P35790 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1044943 | 0.83 | MC4R (1.00) | MC4RPOLBRAB9ASIGMAR1NPC1 | |
| SCHEMBL221139 | 0.83 | MC4R (1.00) | MC4RPOLBRAB9ASIGMAR1NPC1 | |
| SCHEMBL2316820 | 0.83 | MC4R (1.00) | MC4RPOLBRAB9ASIGMAR1NPC1 | |
| SCHEMBL4586698 | 0.83 | ACHE (0.69) | POLBMEN1KMT2ASIGMAR1HTT | |
| SCHEMBL546902 | 0.82 | SMN1; SMN2 (0.62) | MC4RPOLBL3MBTL1MAPK1SMN1; SMN2 | |
| SCHEMBL30059168 | 0.82 | SMN1; SMN2 (0.62) | MC4RPOLBL3MBTL1MAPK1SMN1; SMN2 | |
| SCHEMBL27814575 | 0.82 | ALDH1A1 (0.64) | POLBL3MBTL1RAB9AGAAMAPK1 | |
| Hydrochloric Acid SCHEMBL28900426 | 0.82 | MC4R (0.96) | MC4RPOLBRAB9ASIGMAR1NPC1 | |
| Ammonia Solution, Strong SCHEMBL4261945 | 0.82 | MC4R (0.96) | MC4RPOLBRAB9ASIGMAR1NPC1 | |
| Hydrochloric Acid SCHEMBL11277255 | 0.82 | MC4R (0.96) | MC4RPOLBRAB9ASIGMAR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101379058-B | Pyrazole compounds that modulate the activity of CDK, GSK and aurora kinases | ASTEX THERAPEUTICS LTD | 2014-06-04 | — | — | CN | disclosed |
| CN-101379058-A | Pyrazole compounds that modulate the activity of CDK, GSK and aurora kinases | ASTEX THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | CN | disclosed |