SCHEMBL27749669

SCHEMBL27749669

Nc1cc(Cl)c2c(c1N)C(=O)c1ccccc1C2=O

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 1/20 0.70
CYP1A2 P05177 1/20 0.70
ADORA2A P29274 4/20 0.62
MAOA P21397 2/20 0.55
MAOB P27338 1/20 0.55
CSNK1A1 P48729 2/20 0.53
CSNK1D P48730 2/20 0.53
CSNK1G1 Q9HCP0 2/20 0.53
FGR P09769 1/20 0.53
PIM1 P11309 1/20 0.53
DYRK1A Q13627 1/20 0.53
HIPK2 Q9H2X6 1/20 0.53
MEN1 O00255 5/20 0.50
KMT2A Q03164 5/20 0.50
MAPT P10636 4/20 0.50
MCL1 Q07820 3/20 0.50
MAPK1 P28482 3/20 0.50
THRB P10828 2/20 0.50
PKM P14618 2/20 0.50
NPSR1 Q6W5P4 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL582033 0.87 CYP1A1 (0.72) CYP1A1CYP1A2ADORA2AMAOAMAOB
SCHEMBL11814234 0.86 CYP1A1 (0.54) CYP1A1CYP1A2ADORA2AMAOAMAOB
SCHEMBL7769609 0.85 ADORA2A (0.62) CYP1A1CYP1A2ADORA2AMAOAMAOB
SCHEMBL3581453 0.82 CYP1A1 (1.00) CYP1A1CYP1A2ADORA2AMAOAMAOB
SCHEMBL9619249 0.82 CYP1A1 (0.66) CYP1A1CYP1A2ADORA2AMAOAMAOB
SCHEMBL11879562 0.79 ADORA2A (0.59) CYP1A1CYP1A2ADORA2AMAOAMAOB
SCHEMBL27971804 0.78 CYP1A2 (0.60) CYP1A1CYP1A2ADORA2AMEN1KMT2A
SCHEMBL10618703 0.78 CYP1A1 (0.59) CYP1A1CYP1A2ADORA2AMAOAMAOB
SCHEMBL2254507 0.78 CYP1A1 (0.59) CYP1A1CYP1A2ADORA2AMAOAMAOB
SCHEMBL27918992 0.78 MAPT (0.62) CYP1A1CYP1A2ADORA2AMAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101379144-B Dye and hair dyeing composition DYSTAR TEXTILFARBEN GMBH & CO 2012-08-22 CN disclosed
CN-101379144-A Dye and hair dyeing composition DYSTAR TEXTILFARBEN GMBH & CO (DE) 2009-03-04 CN disclosed