Quinoline

Quinoline

SCHEMBL27749698

CCN1C=CN(C)C1.FC(F)F.c1ccc2ncccc2c1

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.45
SLC6A2 P23975 1/20 0.34
SLC6A4 P31645 1/20 0.34
SLC6A3 Q01959 1/20 0.34
SMN1; SMN2 Q16637 3/20 0.33
CHKA P35790 2/20 0.33
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
LMNA P02545 1/20 0.33
PKM P14618 1/20 0.33
HRH3 Q9Y5N1 2/20 0.33
KDM4E B2RXH2 1/20 0.33
TP53 P04637 1/20 0.33
HPGD P15428 1/20 0.33
HTT P42858 1/20 0.33
HSD17B10 Q99714 1/20 0.33
MET P08581 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Quinoline SCHEMBL27472061 0.95 ALDH1A1 (0.50) ALDH1A1SLC6A2SLC6A4SLC6A3SMN1; SMN2
Quinoline SCHEMBL27925785 0.93 ALDH1A1 (0.49) ALDH1A1SLC6A2SLC6A4SLC6A3SMN1; SMN2
Quinoline SCHEMBL28084990 0.92 ALDH1A1 (0.45) ALDH1A1SLC6A2SLC6A4SLC6A3SMN1; SMN2
Quinoline SCHEMBL27814336 0.87 ALDH1A1 (0.42) ALDH1A1SLC6A2SLC6A4SLC6A3SMN1; SMN2
Quinoline SCHEMBL27860538 0.86 ALDH1A1 (0.41) ALDH1A1SMN1; SMN2NPC1RAB9ALMNA
Quinoline SCHEMBL27939604 0.85 ALDH1A1 (0.49) ALDH1A1SLC6A2SLC6A4SLC6A3SMN1; SMN2
Quinoline SCHEMBL28849626 0.85 ALDH1A1 (0.38) ALDH1A1SMN1; SMN2CHKALMNAKDM4E
Phthalic Acid SCHEMBL28052493 0.84 CHRM5 (0.42) ALDH1A1SMN1; SMN2LMNAKDM4EHTT
Quinoline SCHEMBL28052628 0.84 ALDH1A1 (0.43) ALDH1A1SLC6A2SMN1; SMN2RAB9ALMNA
Quinoline SCHEMBL27584551 0.83 ALDH1A1 (0.46) ALDH1A1SLC6A2SLC6A4SLC6A3SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104341569-B TPUE and preparation method thereof 福建有家家居有限公司 2017-09-26 CN disclosed
CN-101379099-B Fluorine-containing polymer containing heteroaromatic ring DAIKIN IND LTD 2011-01-12 CN disclosed
CN-101379099-A Fluorine-containing polymer containing heteroaromatic ring DAIKIN IND LTD (JP) 2009-03-04 CN disclosed