Quinoline

Quinoline

SCHEMBL28084990

CCN1C=CN(C)C1.CCN1C=CN(C)C1.CCN1C=CN(C)C1.F[B-](F)(F)F.c1ccc2ncccc2c1

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.45
SLC6A2 P23975 1/20 0.34
SLC6A4 P31645 1/20 0.34
SLC6A3 Q01959 1/20 0.34
PDE10A Q9Y233 2/20 0.33
CHKA P35790 2/20 0.33
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
PKM P14618 1/20 0.33
HRH3 Q9Y5N1 2/20 0.33
KDM4E B2RXH2 1/20 0.33
TP53 P04637 1/20 0.33
HPGD P15428 1/20 0.33
HTT P42858 1/20 0.33
HSD17B10 Q99714 1/20 0.33
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
MAPT P10636 1/20 0.32
CYP2C19 P33261 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Quinoline SCHEMBL27472061 0.95 ALDH1A1 (0.50) ALDH1A1SLC6A2SLC6A4SLC6A3PDE10A
Quinoline SCHEMBL27925785 0.93 ALDH1A1 (0.49) ALDH1A1SLC6A2SLC6A4SLC6A3PDE10A
Quinoline SCHEMBL27749698 0.92 ALDH1A1 (0.45) ALDH1A1SLC6A2SLC6A4SLC6A3PDE10A
Quinoline SCHEMBL28233004 0.89 ALDH1A1 (0.41) ALDH1A1SLC6A2SLC6A4SLC6A3PDE10A
Quinoline SCHEMBL27814336 0.87 ALDH1A1 (0.42) ALDH1A1SLC6A2SLC6A4SLC6A3CHKA
Phthalic Acid SCHEMBL28052493 0.87 CHRM5 (0.42) ALDH1A1SMN1; SMN2KDM4EHTTCYP3A4
Quinoline SCHEMBL27860538 0.86 ALDH1A1 (0.41) ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E
Quinoline SCHEMBL27939604 0.85 ALDH1A1 (0.49) ALDH1A1SLC6A2SLC6A4SLC6A3PDE10A
Quinoline SCHEMBL28849626 0.85 ALDH1A1 (0.38) ALDH1A1PDE10ACHKASMN1; SMN2KDM4E
Quinoline SCHEMBL27584551 0.83 ALDH1A1 (0.46) ALDH1A1SLC6A2SLC6A4SLC6A3NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105838350-A Electrochromic composite material and prepared electrochromic device 吉林大学 2016-08-10 CN disclosed