Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13007613 | 0.90 | RXFP1 (0.45) | SCN3ALMNATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL8244471 | 0.87 | KDM4E (0.47) | KDM4ESCN3ALMNATSHRSMN1; SMN2 | |
| SCHEMBL1863465 | 0.86 | SLC40A1 (0.51) | KDM4EALDH1A1SLC40A1MEN1KMT2A | |
| SCHEMBL8244222 | 0.85 | NPC1 (0.57) | SCN3ASMN1; SMN2ALDH1A1PKMMEN1 | |
| SCHEMBL1856352 | 0.82 | KDM4E (0.53) | KDM4ESMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL1857366 | 0.81 | SLC40A1 (0.45) | SCN3ASMN1; SMN2ALDH1A1PKMSLC40A1 | |
| SCHEMBL11959664 | 0.80 | POLB (0.47) | KDM4ESMN1; SMN2ALDH1A1SLC40A1MEN1 | |
| SCHEMBL11959669 | 0.79 | MAPK1 (0.48) | KDM4ESCN3ALMNATSHRALDH1A1 | |
| SCHEMBL14962381 | 0.79 | SLC40A1 (0.48) | KDM4ESCN3ALMNAALDH1A1SLC40A1 | |
| SCHEMBL13007609 | 0.78 | SCN3A (0.47) | SCN3ASMN1; SMN2ALDH1A1PKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101300253-B | Bicyclic derivatives as modulators of voltage gated ion channels | VERTEX PHARMA | 2012-08-22 | — | — | CN | disclosed |
| CN-101300253-A | Bicyclic derivatives as modulators of voltage gated ion channels | VERTEX PHARMA (US) | 2008-11-05 | — | — | CN | disclosed |