Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.43 |
| ▸ | SCN1A | P35498 | 1/20 | 0.43 |
| ▸ | SCN4A | P35499 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27749772 | 0.87 | KDM4E (0.43) | KDM4EALDH1A1MEN1KMT2ASCN3A | |
| SCHEMBL1863465 | 0.87 | SLC40A1 (0.51) | KDM4EALDH1A1MEN1KMT2ASCN1A | |
| SCHEMBL13007613 | 0.87 | RXFP1 (0.45) | ALDH1A1MEN1KMT2ASCN3ALMNA | |
| SCHEMBL8244222 | 0.85 | NPC1 (0.57) | ALDH1A1MEN1KMT2ASCN3ASCN9A | |
| SCHEMBL1856352 | 0.84 | KDM4E (0.53) | KDM4EALDH1A1MEN1KMT2ASCN1A | |
| SCHEMBL1855121 | 0.83 | KMT2A (0.63) | MEN1KMT2ASCN3AHSD17B10LMNA | |
| SCHEMBL11959669 | 0.82 | MAPK1 (0.48) | KDM4EALDH1A1MEN1KMT2ASCN3A | |
| SCHEMBL11959664 | 0.82 | POLB (0.47) | KDM4EALDH1A1MEN1KMT2ASCN1A | |
| SCHEMBL14962381 | 0.80 | SLC40A1 (0.48) | KDM4EALDH1A1MEN1KMT2ASCN3A | |
| SCHEMBL1863212 | 0.80 | KDM4E (0.51) | KDM4EALDH1A1SCN9AMAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007030618-A2 | BICYCLIC DERIVATIVES AS MODULATORS OF VOLTAGE GATED ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-03-15 | — | — | WO | disclosed |