Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 4/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 6/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | BCR | P11274 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL265569 | 0.79 | CCND3 (0.52) | AXLBRD4SYK | |
| SCHEMBL270947 | 0.78 | PLK4 (0.57) | PLK4AXLJAK2SYK | |
| SCHEMBL27751340 | 0.77 | AXL (0.46) | PTK2AXLBRD4SYK | |
| Tert-Butyl Formate SCHEMBL28777983 | 0.76 | LMNA (0.48) | PLK4 | |
| SCHEMBL25550925 | 0.76 | PTK2 (0.50) | PTK2PLK4AXLABL1KIT | |
| Tert-Butyl Formate SCHEMBL27844210 | 0.76 | ACVR1 (0.39) | PTK2ACVR1 | |
| Tert-Butyl Formate SCHEMBL27659431 | 0.73 | TNKS (0.41) | — | |
| Tert-Butyl Formate SCHEMBL27993846 | 0.73 | CXCR4 (0.48) | — | |
| Tert-Butyl Formate SCHEMBL27844700 | 0.72 | HPGD (0.51) | — | |
| Tert-Butyl Formate SCHEMBL27981789 | 0.72 | CXCR4 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103626742-A | Bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN INC | 2014-03-12 | — | — | CN | disclosed |
| CN-101370792-B | Bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN INC | 2013-03-20 | — | — | CN | disclosed |
| CN-101370792-A | Bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN INC (US) | 2009-02-18 | — | — | CN | disclosed |