Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CXCR4 | P61073 | 12/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butyl Formate SCHEMBL27993846 | 0.88 | CXCR4 (0.48) | CXCR4MEN1CHRM2CHRM1ADRA2C | |
| Tert-Butyl Formate SCHEMBL27981789 | 0.86 | CXCR4 (0.47) | LMNACXCR4MEN1CHRM2CHRM1 | |
| Tert-Butyl Formate SCHEMBL27524789 | 0.86 | SIGMAR1 (0.66) | LMNACXCR4MEN1CHRM2CHRM1 | |
| Tert-Butyl Formate SCHEMBL28055969 | 0.85 | CHRM3 (0.49) | CXCR4CHRM2SIGMAR1 | |
| Tert-Butyl Formate SCHEMBL28277617 | 0.85 | CXCR4 (0.43) | CXCR4MEN1CHRM2CHRM1ADRA2C | |
| Tert-Butyl Formate SCHEMBL28277618 | 0.85 | CXCR4 (0.43) | CXCR4MEN1CHRM2CHRM1ADRA2C | |
| Tert-Butyl Formate SCHEMBL27844700 | 0.84 | HPGD (0.51) | CXCR4MEN1CHRM2CHRM1ADRA2C | |
| Ethoxycarbonyl Group SCHEMBL27721350 | 0.84 | LMNA (0.48) | LMNACXCR4MEN1CHRM2CHRM1 | |
| Tert-Butyl Formate SCHEMBL27659431 | 0.84 | TNKS (0.41) | LMNACXCR4MEN1CHRM2CHRM1 | |
| Tert-Butyl Formate SCHEMBL27844210 | 0.84 | ACVR1 (0.39) | CXCR4MEN1CHRM2CHRM1ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103626742-A | Bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN INC | 2014-03-12 | — | — | CN | disclosed |
| CN-101981036-B | Pyrrolo [2, 3-D] pyridines and use thereof as tyrosine kinase inhibitors | NOVARTIS AG | 2013-09-04 | — | — | CN | disclosed |
| CN-101370792-B | Bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN INC | 2013-03-20 | — | — | CN | disclosed |
| CN-101506155-A | Biphenyl derivatives and their use in the treatment of hepatitis C | ARROW THERAPEUTICS LTD (GB) | 2009-08-12 | — | — | CN | disclosed |
| CN-101370792-A | Bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN INC (US) | 2009-02-18 | — | — | CN | disclosed |