Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | KHK | P50053 | 1/20 | 0.34 |
| ▸ | F7 | P08709 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28778027 | 0.81 | IRAK4 (0.40) | KDM4ENPC1RAB9APAX8CYP11B1 | |
| SCHEMBL5635166 | 0.78 | CYP11B1 (0.40) | KDM4ENPC1RAB9APAX8CYP11B1 | |
| SCHEMBL15904082 | 0.68 | PDE10A (0.51) | CYP11B1CYP11B2PDE10AKHKLRRK2 | |
| SCHEMBL6281434 | 0.67 | AURKA (0.55) | KDM4ENPC1RAB9APAX8 | |
| SCHEMBL24976098 | 0.66 | PLAU (0.39) | BACE1NCF1NOS2F7MEN1 | |
| SCHEMBL6664820 | 0.65 | TRPA1 (0.45) | BACE1KDM4ENPC1RAB9APAX8 | |
| SCHEMBL13052911 | 0.65 | CYP11B2 (0.55) | KDM4ENPC1RAB9ACYP11B1CYP11B2 | |
| SCHEMBL20603936 | 0.63 | MGAM (0.49) | KDM4ENPC1RAB9ACYP11B1CYP11B2 | |
| SCHEMBL14688616 | 0.63 | PDE10A (0.43) | KDM4ECYP11B1CYP11B2PDE10AMGAM | |
| SCHEMBL2627244 | 0.63 | IRAK4 (0.53) | KDM4ENPC1RAB9ACYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101440092-B | 2-indazole-4-aza indole-5-amino derivatives, and preparation and use thereof | UNIV ZHEJIANG | 2010-11-17 | — | — | CN | claimed |
| CN-101440092-A | 2-indazole-4-aza indole-5-amino derivatives, and preparation and use thereof | UNIV ZHEJIANG (CN) | 2009-05-27 | — | — | CN | claimed |
| CN-101440092-B | 2-indazole-4-aza indole-5-amino derivatives, and preparation and use thereof | UNIV ZHEJIANG | 2010-11-17 | — | — | CN | disclosed |
| CN-101440092-B | 2-indazole-4-aza indole-5-amino derivatives, and preparation and use thereof | UNIV ZHEJIANG | 2010-11-17 | — | — | CN | disclosed |
| CN-101440092-A | 2-indazole-4-aza indole-5-amino derivatives, and preparation and use thereof | UNIV ZHEJIANG (CN) | 2009-05-27 | — | — | CN | disclosed |
| CN-101440092-A | 2-indazole-4-aza indole-5-amino derivatives, and preparation and use thereof | UNIV ZHEJIANG (CN) | 2009-05-27 | — | — | CN | disclosed |