Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.56 |
| ▸ | CTSA | P10619 | 11/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12746075 | 1.00 | LMNA (0.71) | LMNAHPGDHTTALOX15TSHR | |
| SCHEMBL1171873 | 1.00 | LMNA (0.71) | LMNAHPGDHTTALOX15TSHR | |
| SCHEMBL13183083 | 0.83 | SMN1; SMN2 (0.49) | LMNAHPGDHTTALOX15TSHR | |
| SCHEMBL12863942 | 0.76 | POLB (0.50) | LMNAHPGDHTTALOX15TSHR | |
| SCHEMBL1172432 | 0.75 | CTSA (0.51) | LMNAHPGDHTTALOX15TSHR | |
| SCHEMBL12746073 | 0.75 | CTSA (0.51) | LMNAHPGDHTTALOX15TSHR | |
| SCHEMBL1172003 | 0.74 | MRGPRX4 (0.54) | SMN1; SMN2PTGER4MRGPRX4 | |
| SCHEMBL477599 | 0.73 | SMN1; SMN2 (0.62) | LMNAHPGDHTTALOX15TSHR | |
| SCHEMBL379281 | 0.72 | MAOB (0.67) | ALOX5MRGPRX4 | |
| SCHEMBL2137838 | 0.71 | MRGPRX4 (0.69) | ALOX5MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2203412-A1 | MONOACYLGLYCEROL LIPASE INHIBITORS FOR MODULATION OF CANNABINOID ACTIVITY | NORTHEASTERN UNIVERSITY (US) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009052319-A1 | MONOACYLGLYCEROL LIPASE INHIBITORS FOR MODULATION OF CANNABINOID ACTIVITY | NORTHEASTERN UNIVERSITY (US) | 2009-04-23 | — | — | WO | disclosed |