Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SELL | P14151 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SELP | P16109 | 1/20 | 0.41 |
| ▸ | FUT4 | P22083 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27820303 | 0.83 | ALDH1A1 (0.39) | ALDH1A1TP53LMNAMAPTMAPK1 | |
| SCHEMBL27751834 | 0.81 | TTR (0.56) | ALDH1A1CA12CA1CA2CA7 | |
| SCHEMBL4587381 | 0.79 | CASP6 (0.46) | ALDH1A1TP53TDP1LMNAMAPK1 | |
| SCHEMBL27688707 | 0.79 | CASP6 (0.46) | TP53TDP1LMNAMAPK1HCAR3 | |
| SCHEMBL31447507 | 0.77 | CA12 (0.60) | ALDH1A1CA12CA1CA2CA7 | |
| SCHEMBL27666863 | 0.76 | ALDH1A1 (0.44) | ALDH1A1TP53TDP1LMNAMAPT | |
| SCHEMBL27463068 | 0.76 | TPMT (0.42) | ALDH1A1TP53TDP1KDM4ELMNA | |
| SCHEMBL3768831 | 0.75 | TTR (0.55) | ALDH1A1TP53TDP1KDM4ELMNA | |
| SCHEMBL28763291 | 0.74 | ALDH1A1 (0.40) | ALDH1A1TP53TDP1HPGDSMN1; SMN2 | |
| SCHEMBL27449631 | 0.74 | TPMT (0.44) | ALDH1A1CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101379044-A | Heterobicyclic sulfonamide derivatives for the treatment of diabetes | HOFFMANN LA ROCHE (CH) | 2009-03-04 | — | — | CN | disclosed |