Broxuridine

Broxuridine

SCHEMBL27755

O=c1[nH]c(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1Br

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TK1 P04183 3/20 0.73
LMNA P02545 2/20 0.73
SMN1; SMN2 Q16637 2/20 0.73
CYP1A2 P05177 1/20 0.69
CYP3A4 P08684 1/20 0.69
TSHR P16473 1/20 0.69
BLM P54132 1/20 0.69
PMP22 Q01453 1/20 0.69
NPSR1 Q6W5P4 1/20 0.69
ALOX12 P18054 1/20 0.69
ADRA1A P35348 1/20 0.69
TK2 O00142 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Broxuridine SCHEMBL37420 1.00 TK1 (0.73) TK1LMNASMN1; SMN2CYP1A2CYP3A4
Broxuridine SCHEMBL10316347 1.00 TK1 (0.73) TK1LMNASMN1; SMN2CYP1A2CYP3A4
Broxuridine SCHEMBL65484 1.00 TK1 (0.73) TK1LMNASMN1; SMN2CYP1A2CYP3A4
Broxuridine SCHEMBL14457631 1.00 TK1 (0.73) TK1LMNASMN1; SMN2CYP1A2CYP3A4
Broxuridine SCHEMBL27756 1.00 TK1 (0.73) TK1LMNASMN1; SMN2CYP1A2CYP3A4
Broxuridine SCHEMBL9153195 1.00 TK1 (0.73) TK1LMNASMN1; SMN2CYP1A2CYP3A4
Broxuridine SCHEMBL20769775 1.00 TK1 (0.73) TK1LMNASMN1; SMN2CYP1A2CYP3A4
Broxuridine SCHEMBL21137660 1.00 TK1 (0.73) TK1LMNASMN1; SMN2CYP1A2CYP3A4
Broxuridine SCHEMBL21423028 1.00 TK1 (0.73) TK1LMNASMN1; SMN2CYP1A2CYP3A4
Broxuridine SCHEMBL5981680 1.00 TK1 (0.73) TK1LMNASMN1; SMN2CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 22388 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12612662-B2 DNA repair site detection for personal genomics, epigenomics, and gene therapy SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2026-04-28 US claimed
EP-3990021-B1 INHIBITION OF DIPEPTIDE REPEAT PROTEINS ALS THERAPY DEVELOPMENT INST (US) 2026-03-18 EP claimed
US-20260071273-A1 METHODS FOR NUCLEIC ACID SEQUENCING NANOHYB LLC (US) 2026-03-12 US claimed
EP-4677107-A1 METHOD FOR NATIVE STRAND SEQUENCING OF ENRICHED GENOMIC REGIONS Nanohyb, LLC (US) 2026-01-14 EP claimed
US-20260007635-A1 INHIBITION OF DIPEPTIDE REPEAT PROTEINS ALS THERAPY DEVELOPMENT INST (US) 2026-01-08 US claimed
EP-4646488-A1 ENZYMATIC DNA SYNTHESIS The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone (US) 2025-11-12 EP claimed
US-12447231-B2 Human placental tissue graft products, methods, and apparatuses CRYOLIFE, INC. (US) 2025-10-21 US claimed
EP-4623073-A2 METHODS FOR ASSESSING PROLIFERATION POTENCY OF GENE-EDITED T CELLS Iovance Biotherapeutics, Inc. (US) 2025-10-01 EP claimed
EP-3821033-B1 USE OF DROPLET SINGLE CELL EPIGENOME PROFILING FOR PATIENT STRATIFICATION HIFIBIO SAS (FR) 2025-09-10 EP claimed
US-20250275946-A1 COMBINATION THERAPY FOR THE TREATMENT OF CANCER UNM RAINFOREST INNOVATIONS (US) 2025-09-04 US claimed
EP-0119025-B1 THYMIDINE KINASE-NEGATIVE TEMPERATURE RESISTANT BOVINE HERPESVIRUS-1 MUTANT AS A VACCINE AGAINST INFECTIOUS BOVINE RHINOTRACHEITIS Baylor College of Medicine (US) 1989-09-13 EP claimed
EP-0306985-A2 Bacteriorhodopsin modifications and methods for their preparation Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 1989-03-15 EP claimed
US-4812394-A Flow cytomeric measurement of DNA and incorporated nucleoside analogs UNIVERSITY OF CALIFORNIA (US) 1989-03-14 US claimed
US-4766067-A Gene amplification PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1988-08-23 US claimed
EP-0175286-A2 In vitro cell culture system and method MCW Research Foundation, Inc. (US) 1986-03-26 EP claimed
US-4569840-A Thymidine kinase-negative temperature resistant bovine herpesvirus-1 mutant as a vaccine against infectious bovine rhinotracheitis BAYLOR COLLEGE OF MEDICINE (US) 1986-02-11 US claimed
US-4529700-A Hybridoma cells secreting a monoclonal antibody specific for 5-bromo and 5-iodoeoxyuridine and reagents for measuring cellular proliferation UNIVERSITY OF MIAMI (US) 1985-07-16 US claimed
EP-0119025-A2 Thymidine kinase-negative temperature resistant bovine herpesvirus-1 mutant as a vaccine against infectious bovine rhinotracheitis Baylor College of Medicine (US) 1984-09-19 EP claimed
US-4465769-A Non-transformed thymidine kinaseless cell line and its use for testing tumorigenic potential of genes THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1984-08-14 US claimed
EP-0102228-A2 Hybridoma secreting a monoclonal antibody specific for 5-bromo and 5-iododeoxyuridine and reagent for measuring cellular proliferation UNIVERSITY OF MIAMI (US) 1984-03-07 EP claimed