Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27755225 | 0.90 | LCK (0.44) | LCKCDK4CCND1GSK3BKMT2A | |
| SCHEMBL27775654 | 0.85 | ACE2 (0.47) | KMT2AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL27776041 | 0.83 | ALDH1A1 (0.47) | LCKCDK4CCND1GSK3BKMT2A | |
| SCHEMBL27776073 | 0.82 | CDK4 (0.63) | LCKCDK4CCND1GSK3BKMT2A | |
| SCHEMBL27775653 | 0.82 | CDK4 (0.46) | LCKCDK4CCND1GSK3BKMT2A | |
| SCHEMBL27754972 | 0.75 | ACE2 (0.47) | KMT2AMEN1KDM4EPARP1 | |
| SCHEMBL27775912 | 0.74 | GSK3B (0.69) | CDK4CCND1GSK3BKMT2AMEN1 | |
| SCHEMBL27775823 | 0.73 | KDM4E (0.51) | LCKCDK4CCND1GSK3BKMT2A | |
| SCHEMBL27754988 | 0.72 | CDK4 (0.63) | LCKCDK4CCND1GSK3BKMT2A | |
| SCHEMBL27754969 | 0.71 | CDK4 (0.46) | LCKCDK4CCND1GSK3BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101519372-B | Benzo [e] isoindazole-1,3 diketone compound used as GSK inhibiting agent and preparation method thereof | SHENZHEN SHENGJIE BIOLOGY TECHNOLOGY CO LTD | 2011-07-20 | — | — | CN | disclosed |
| CN-101519372-A | Benzo [e] isoindazole-1,3 diketone compound used as GSK inhibiting agent and preparation method thereof | SHENZHEN SHENGJIE BIOLOGY TECH | 2009-09-02 | — | — | CN | disclosed |