Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.69 |
| ▸ | CDK4 | P11802 | 1/20 | 0.69 |
| ▸ | CCND1 | P24385 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27755297 | 0.85 | CDK4 (0.50) | GSK3BCDK4CCND1KDM4EALDH1A1 | |
| SCHEMBL27775655 | 0.83 | GSK3B (0.66) | GSK3BCDK4CCND1KDM4EALDH1A1 | |
| SCHEMBL27755291 | 0.81 | GSK3B (1.00) | GSK3BCDK4CCND1KDM4EALDH1A1 | |
| SCHEMBL27755295 | 0.81 | GSK3B (0.78) | GSK3BCDK4CCND1KDM4EALDH1A1 | |
| SCHEMBL27755227 | 0.78 | GSK3B (0.73) | GSK3BCDK4CCND1KDM4EALDH1A1 | |
| SCHEMBL27755225 | 0.74 | LCK (0.44) | GSK3BCDK4CCND1KDM4EALDH1A1 | |
| SCHEMBL27755149 | 0.74 | LCK (0.44) | GSK3BCDK4CCND1KDM4EALDH1A1 | |
| SCHEMBL20738337 | 0.74 | KDM4E (0.49) | GSK3BCDK4CCND1KDM4EALDH1A1 | |
| SCHEMBL27754984 | 0.72 | CDK4 (0.53) | GSK3BCDK4CCND1KDM4EALDH1A1 | |
| SCHEMBL2424940 | 0.70 | KDM4E (0.54) | GSK3BCDK4CCND1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101519372-B | Benzo [e] isoindazole-1,3 diketone compound used as GSK inhibiting agent and preparation method thereof | SHENZHEN SHENGJIE BIOLOGY TECHNOLOGY CO LTD | 2011-07-20 | — | — | CN | disclosed |
| CN-101519372-A | Benzo [e] isoindazole-1,3 diketone compound used as GSK inhibiting agent and preparation method thereof | SHENZHEN SHENGJIE BIOLOGY TECH | 2009-09-02 | — | — | CN | disclosed |