Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 1.00 |
| ▸ | CDK4 | P11802 | 1/20 | 1.00 |
| ▸ | CCND1 | P24385 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27755295 | 0.88 | GSK3B (0.78) | GSK3BCDK4CCND1ALDH1A1KDM4E | |
| SCHEMBL27755227 | 0.84 | GSK3B (0.73) | GSK3BCDK4CCND1ALDH1A1KDM4E | |
| SCHEMBL27775912 | 0.81 | GSK3B (0.69) | GSK3BCDK4CCND1ALDH1A1KDM4E | |
| SCHEMBL27775655 | 0.80 | GSK3B (0.66) | GSK3BCDK4CCND1ALDH1A1KDM4E | |
| SCHEMBL27776073 | 0.77 | CDK4 (0.63) | GSK3BCDK4CCND1ALDH1A1KDM4E | |
| SCHEMBL27754988 | 0.77 | CDK4 (0.63) | GSK3BCDK4CCND1ALDH1A1KDM4E | |
| SCHEMBL27775657 | 0.73 | CDK4 (0.57) | GSK3BCDK4CCND1KDM4EMAPT | |
| SCHEMBL1788512 | 0.70 | ALDH1A1 (0.58) | GSK3BCDK4CCND1ALDH1A1KDM4E | |
| SCHEMBL27754984 | 0.69 | CDK4 (0.53) | GSK3BCDK4CCND1ALDH1A1KDM4E | |
| SCHEMBL27754996 | 0.69 | CDK4 (0.53) | GSK3BCDK4CCND1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101519372-B | Benzo [e] isoindazole-1,3 diketone compound used as GSK inhibiting agent and preparation method thereof | SHENZHEN SHENGJIE BIOLOGY TECHNOLOGY CO LTD | 2011-07-20 | — | — | CN | disclosed |
| CN-101519372-A | Benzo [e] isoindazole-1,3 diketone compound used as GSK inhibiting agent and preparation method thereof | SHENZHEN SHENGJIE BIOLOGY TECH | 2009-09-02 | — | — | CN | disclosed |