Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | CTSS | P25774 | 3/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27755247 | 0.82 | PTPN1 (0.47) | GAACES2CES1HPGDKDM4E | |
| SCHEMBL2325174 | 0.78 | SLC6A2 (0.38) | SLC6A2SLC6A4P2RX7P2RX1CMA1 | |
| SCHEMBL2325182 | 0.77 | SLC6A2 (0.39) | SLC6A2SLC6A4P2RX7P2RX1CMA1 | |
| SCHEMBL28856658 | 0.77 | CES2 (0.44) | CES2CES1KDM4EMEN1KMT2A | |
| SCHEMBL28107151 | 0.77 | PDK2 (0.44) | SLC6A2SLC6A4P2RX7P2RX1CMA1 | |
| SCHEMBL27775785 | 0.73 | KCNK3 (0.46) | KMT2AALDH1A1HTT | |
| SCHEMBL27775801 | 0.72 | KCNK3 (0.37) | P2RX1GAACES2MEN1KMT2A | |
| SCHEMBL27775828 | 0.72 | KMT2A (0.40) | P2RX7CES2KMT2AMAPT | |
| SCHEMBL2324567 | 0.71 | SOS1 (0.47) | SLC6A2SLC6A4HPGDKDM4EKMT2A | |
| SCHEMBL27831826 | 0.71 | ERCC5 (0.49) | HPGDKDM4EMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101528713-A | Pyridazine derivatives as inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 | HOFFMANN LA ROCHE (CH) | 2009-09-09 | — | — | CN | disclosed |