Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 1/20 | 0.37 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.35 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27775828 | 0.89 | KMT2A (0.40) | KCNK3KCNK9HCRTR1HCRTR2CES2 | |
| SCHEMBL27755386 | 0.85 | HTT (0.46) | LMNATMPRSS4MAPTHTTRAB9A | |
| SCHEMBL27755234 | 0.78 | NPC1 (0.39) | CES2MAPTKMT2AHTTMEN1 | |
| SCHEMBL2325106 | 0.78 | EPHX2 (0.38) | KCNK3KCNK9HCRTR1HCRTR2CES2 | |
| SCHEMBL2325110 | 0.77 | KCNK3 (0.37) | KCNK3KCNK9HCRTR1HCRTR2CES2 | |
| SCHEMBL26020578 | 0.77 | CES2 (0.43) | KCNK3KCNK9HCRTR1HCRTR2CES2 | |
| SCHEMBL27775993 | 0.77 | HPGD (0.44) | MAPTKMT2ANPC1RAB9A | |
| SCHEMBL16914396 | 0.74 | PTPN1 (0.47) | HCRTR1HCRTR2CES2LMNAGAA | |
| SCHEMBL27776094 | 0.72 | NPC1 (0.48) | CES2LMNAMAPTPKMNPC1 | |
| SCHEMBL27755344 | 0.72 | SLC6A2 (0.38) | CES2LMNAGAAP2RX1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101528713-A | Pyridazine derivatives as inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 | HOFFMANN LA ROCHE (CH) | 2009-09-09 | — | — | CN | disclosed |