Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 19/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 18/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2776538 | 1.00 | MTNR1B (0.46) | MTNR1BMTNR1ASLC6A4 | |
| SCHEMBL2777449 | 1.00 | MTNR1B (0.46) | MTNR1BMTNR1ASLC6A4 | |
| SCHEMBL543708 | 0.91 | MTNR1B (0.50) | MTNR1BMTNR1ASLC6A4 | |
| SCHEMBL543564 | 0.91 | MTNR1B (0.50) | MTNR1BMTNR1ASLC6A4 | |
| SCHEMBL544113 | 0.91 | MTNR1B (0.50) | MTNR1BMTNR1ASLC6A4 | |
| SCHEMBL543467 | 0.89 | MTNR1B (0.59) | MTNR1BMTNR1ASLC6A4 | |
| SCHEMBL543804 | 0.89 | MTNR1B (0.59) | MTNR1BMTNR1ASLC6A4 | |
| SCHEMBL543691 | 0.89 | MTNR1B (0.59) | MTNR1BMTNR1ASLC6A4 | |
| SCHEMBL543466 | 0.89 | MTNR1B (0.59) | MTNR1BMTNR1ASLC6A4 | |
| SCHEMBL10257834 | 0.85 | ADORA3 (0.42) | MTNR1BMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141150-B1 | BICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2013-12-11 | — | — | EP | disclosed |
| EP-2141150-A1 | BICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-01-06 | — | — | EP | disclosed |