Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.54 |
| ▸ | MAX | P61244 | 1/20 | 0.54 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | CTSV | O60911 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3664743 | 0.86 | MYC (0.47) | MYCMAXPTGDR2MAPTALDH1A1 | |
| SCHEMBL6775236 | 0.85 | PTGS2 (0.54) | PTGDR2MAPTALDH1A1TSHRPTGS2 | |
| SCHEMBL623566 | 0.82 | ALDH1A1 (0.54) | CTSVCTSLMAPTALDH1A1TSHR | |
| SCHEMBL6641665 | 0.80 | MYC (0.66) | MYCMAXPTGDR2CTSVCTSL | |
| SCHEMBL630072 | 0.80 | MYC (0.62) | MYCMAXPTGDR2CTSVCTSL | |
| SCHEMBL31376933 | 0.80 | MYC (0.62) | MYCMAXPTGDR2CTSVCTSL | |
| SCHEMBL11074241 | 0.79 | MYC (0.52) | MYCMAXPTGDR2CTSVCTSL | |
| SCHEMBL6781590 | 0.79 | PTGDR2 (0.52) | MYCMAXPTGDR2MAPTALDH1A1 | |
| SCHEMBL6624800 | 0.78 | MYC (0.54) | MYCMAXPTGDR2CTSVCTSL | |
| SCHEMBL30406917 | 0.77 | ALDH1A1 (0.50) | CTSVCTSLMAPTALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101903355-B | Imidazole-substituted arylamides | HOFFMANN LA ROCHE | 2014-05-14 | — | — | CN | disclosed |
| CN-101903348-B | Pyrazole-substituted arylamides | HOFFMANN LA ROCHE | 2013-08-14 | — | — | CN | disclosed |
| CN-103159692-A | Tetrazole-substituted arylamides | HOFFMANN LA ROCHE | 2013-06-19 | — | — | CN | disclosed |
| CN-101903359-B | Triazole-substituted arylamide derivatives and their use as P2X3 and/or P2X2/3 purinergic receptor antagonists | HOFFMANN LA ROCHE | 2013-05-22 | — | — | CN | disclosed |
| CN-101479250-B | Tetrazole-substituted arylamides | HOFFMANN LA ROCHE | 2013-05-22 | — | — | CN | disclosed |
| CN-101528717-B | Thiazole and oxazole-substituted arylamides | HOFFMANN LA ROCHE | 2013-04-24 | — | — | CN | disclosed |
| CN-102438989-A | Novel oxazolone and pyrrolidinone-substituted arylamides | HOFFMANN LA ROCHE | 2012-05-02 | — | — | CN | disclosed |
| CN-101903355-A | Novel imidazole-substituted arylamides | HOFFMANN LA ROCHE | 2010-12-01 | — | — | CN | disclosed |
| CN-101903348-A | Novel pyrazole-substituted arylamides | HOFFMANN LA ROCHE | 2010-12-01 | — | — | CN | disclosed |
| CN-101903359-A | Triazole-substituted arylamide derivatives and their use as P2X3And/or P2X2/3Use of purinergic receptor antagonists | HOFFMANN LA ROCHE | 2010-12-01 | — | — | CN | disclosed |
| CN-101528717-A | Thiazole and oxazole-substituted arylamides | HOFFMANN LA ROCHE (CH) | 2009-09-09 | — | — | CN | disclosed |