Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | SMO | Q99835 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | TGM2 | P21980 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27756943 | 0.84 | TSHR (0.50) | SMN1; SMN2MAPTHPGDCHRM2ALDH1A1 | |
| SCHEMBL27757137 | 0.84 | SMO (0.48) | LMNASMN1; SMN2MAPTHTTHPGD | |
| SCHEMBL27736435 | 0.82 | ME2 (0.42) | MAPTHTTSMOALDH1A1KMT2A | |
| SCHEMBL1904861 | 0.81 | SMN1; SMN2 (0.60) | LMNASMN1; SMN2MAPTHTTHPGD | |
| SCHEMBL27757116 | 0.79 | GRM5 (0.46) | LMNASMN1; SMN2MAPTALDH1A1MEN1 | |
| SCHEMBL27736433 | 0.78 | MEN1 (0.47) | MEN1KMT2AGAA | |
| SCHEMBL27736436 | 0.77 | TSHR (0.62) | LMNASMN1; SMN2MAPTHTTKDM4E | |
| SCHEMBL1706076 | 0.76 | SMN1; SMN2 (0.57) | LMNASMN1; SMN2MAPTHTTHPGD | |
| SCHEMBL27757123 | 0.75 | TGM2 (0.44) | HTTTGM2ALDH1A1MEN1KMT2A | |
| SCHEMBL27756961 | 0.74 | KMT2A (0.65) | LMNASMN1; SMN2MAPTKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101405266-A | Piperazines and piperidines as mGlur5 potentiators | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | CN | claimed |