Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 8/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.52 |
| ▸ | HTR2A | P28223 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.52 |
| ▸ | HRH2 | P25021 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2774155 | 0.86 | SLC6A4 (0.56) | CHRM5CHRM1HTR2AKCNH2SLC6A4 | |
| SCHEMBL3955606 | 0.84 | CHRM5 (0.49) | CHRM5CHRM1HTR2AKCNH2SLC6A4 | |
| SCHEMBL2774753 | 0.81 | CHRM5 (0.56) | CHRM5CHRM1HTR2AKCNH2SLC6A4 | |
| SCHEMBL22634126 | 0.78 | HTR2A (0.70) | HTR2AKCNH2DRD2HTR2CCA12 | |
| SCHEMBL2774544 | 0.77 | HTR2A (0.43) | CHRM5HTR2AKCNH2SLC6A4DRD2 | |
| SCHEMBL2776390 | 0.77 | SLC6A4 (0.54) | CHRM5CHRM1HTR2AKCNH2SLC6A4 | |
| SCHEMBL2774716 | 0.75 | CHRM5 (0.61) | CHRM5CHRM1HTR2AKCNH2SLC6A4 | |
| SCHEMBL2773429 | 0.75 | CHRM5 (0.61) | CHRM5CHRM1HTR2AKCNH2SLC6A4 | |
| SCHEMBL3949670 | 0.75 | CHRM5 (0.61) | CHRM5CHRM1HTR2AKCNH2SLC6A4 | |
| SCHEMBL3950616 | 0.75 | CHRM5 (0.61) | CHRM5CHRM1HTR2AKCNH2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010112488-A1 | METHOD FOR OBTAINING 1,3-DIFUNCTIONALIZED PYRROLIDINE DERIVATIVES | RAGACTIVES, S.L.U. (ES) | 2010-10-07 | — | — | WO | claimed |
| EP-2236509-A1 | Method for obtaining 1,3-difunctionalized pyrrolidine derivatives | Ragactives, S.L. (ES) | 2010-10-06 | — | — | EP | claimed |
| US-20200384168-A1 | DEVICES AND METHODS FOR TREATING SPINAL CORD TISSUE | WAKE FOREST UNIVERSITY HEALTH SCIENCES, CORPORATION | 2020-12-10 | — | — | US | disclosed |
| US-10632235-B2 | Devices and methods for treating spinal cord tissue | WAKE FOREST UNIVERSITY HEALTH SCIENCES (US) | 2020-04-28 | — | — | US | disclosed |
| US-20170368242-A1 | DEVICES AND METHODS FOR TREATING SPINAL CORD TISSUE | WAKE FOREST UNIVERSITY HEALTH SCIENCES | 2017-12-28 | — | — | US | disclosed |
| EP-2205189-B1 | DEVICES FOR TREATING SPINAL CORD TISSUE | UNIV WAKE FOREST HEALTH SCIENCES (US) | 2017-12-06 | — | — | EP | disclosed |
| US-20140350499-A1 | DEVICES AND METHODS FOR TREATING SPINAL CORD TISSUE | WAKE FOREST UNIVERSITY | 2014-11-27 | — | — | US | disclosed |
| US-20140350497-A1 | DEVICE AND METHOD FOR TREATING CENTRAL NERVOUS SYSTEM PATHOLOGY | WAKE FOREST UNIVERSITY HEALTH SCIENCES | 2014-11-27 | — | — | US | disclosed |
| US-8834520-B2 | Devices and methods for treating spinal cord tissue | WAKE FOREST UNIVERSITY (US) | 2014-09-16 | — | — | US | disclosed |
| US-8764794-B2 | Device and method for treating central nervous system pathology | WAKE FOREST UNIVERSITY HEALTH SCIENCES (US) | 2014-07-01 | — | — | US | disclosed |
| US-20130072827-A1 | DEVICE AND METHOD FOR TREATING CENTRAL NERVOUS SYSTEM PATHOLOGY | WAKE FOREST UNIVERSITY HEALTH SCIENCES (US) | 2013-03-21 | — | — | US | disclosed |
| US-8267960-B2 | Device and method for treating central nervous system pathology | WAKE FOREST UNIVERSITY HEALTH SCIENCES (US) | 2012-09-18 | — | — | US | disclosed |
| EP-2237812-A1 | DEVICE AND METHOD FOR TREATING CENTRAL NERVOUS SYSTEM PATHOLOGY | Wake Forest University Health Sciences (US) | 2010-10-13 | — | — | EP | disclosed |
| WO-2010112488-A1 | METHOD FOR OBTAINING 1,3-DIFUNCTIONALIZED PYRROLIDINE DERIVATIVES | RAGACTIVES, S.L.U. (ES) | 2010-10-07 | — | — | WO | disclosed |
| EP-2236509-A1 | Method for obtaining 1,3-difunctionalized pyrrolidine derivatives | Ragactives, S.L. (ES) | 2010-10-06 | — | — | EP | disclosed |
| EP-2205189-A1 | DEVICES AND METHODS FOR TREATING SPINAL CORD TISSUE | Wake Forest University Health Sciences (US) | 2010-07-14 | — | — | EP | disclosed |
| US-20090254120-A1 | DEVICE AND METHOD FOR TREATING CENTRAL NERVOUS SYSTEM PATHOLOGY | WAKE FOREST UNIVERSITY HEALTH SCIENCES | 2009-10-08 | — | — | US | disclosed |
| US-20090187259-A1 | DEVICES AND METHODS FOR TREATING SPINAL CORD TISSUE | WAKE FOREST UNIVERSITY HEALTH SCIENCES | 2009-07-23 | — | — | US | disclosed |
| WO-2009089435-A1 | DEVICE AND METHOD FOR TREATING CENTRAL NERVOUS SYSTEM PATHOLOGY | WAKE FOREST UNIVERSITY HEALTH SCIENCES (US) | 2009-07-16 | — | — | WO | disclosed |
| WO-2009049058-A1 | DEVICES AND METHODS FOR TREATING SPINAL CORD TISSUE | WAKE FOREST UNIVERSITY HEALTH SCIENCES (US) | 2009-04-16 | — | — | WO | disclosed |