Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 5/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27759408 | 0.78 | MGLL (0.50) | TLR9PKMALDH1A1MGLL | |
| SCHEMBL8980795 | 0.73 | KMT2A (0.50) | RAB9A | |
| SCHEMBL28090496 | 0.70 | MGLL (0.54) | PKMALDH1A1MAPK1MGLL | |
| SCHEMBL915633 | 0.70 | CES1 (0.64) | ALDH1A1 | |
| SCHEMBL2342931 | 0.69 | HPGD (0.65) | TLR9EGLN1MAPTPKM | |
| SCHEMBL8314729 | 0.68 | CES1 (0.44) | EGLN1NR1H2NPC1MAPTPKM | |
| SCHEMBL27967962 | 0.67 | P2RX4 (0.40) | EGLN1NPC1MAPTPKMRAB9A | |
| SCHEMBL24462527 | 0.64 | EGLN1 (0.41) | EGLN1NPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL17047745 | 0.63 | PARP1 (0.40) | NPC1MAPTPKMRAB9AHCAR1 | |
| SCHEMBL7671094 | 0.63 | MAPT (0.56) | NPC1MAPTPKMRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101378750-B | Indolone compounds useful to treat cognitive impairment | HELICON THERAPEUTICS INC | 2012-07-18 | — | — | CN | disclosed |
| CN-101378750-A | Indolone compounds useful to treat cognitive impairment | HELICON THERAPEUTICS INC (US) | 2009-03-04 | — | — | CN | disclosed |