Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | NCEH1 | Q6PIU2 | 3/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27673955 | 0.86 | NR1H4 (0.34) | PLAUSSTR4NR1H4GRM4 | |
| SCHEMBL24493279 | 0.86 | NCEH1 (0.42) | PLAUNCEH1PLGPLATSSTR4 | |
| SCHEMBL29650188 | 0.86 | NCEH1 (0.42) | PLAUNCEH1PLGPLATSSTR4 | |
| SCHEMBL7220504 | 0.78 | PLG (0.43) | PLAUNCEH1PLGPLATSSTR4 | |
| SCHEMBL29508504 | 0.75 | PDPK1 (0.36) | PLAUSSTR4AAK1NR1H4GRM4 | |
| SCHEMBL29649948 | 0.75 | PDPK1 (0.36) | PLAUSSTR4AAK1NR1H4GRM4 | |
| SCHEMBL1438293 | 0.75 | PDPK1 (0.36) | PLAUSSTR4AAK1NR1H4GRM4 | |
| SCHEMBL8233620 | 0.72 | GABRG2 (0.39) | SSTR4AAK1NR1H4GRM4GABRA1 | |
| SCHEMBL29649968 | 0.72 | ATR (0.41) | PLAUNCEH1AAK1LMNAL3MBTL1 | |
| SCHEMBL24493062 | 0.72 | ATR (0.41) | PLAUNCEH1AAK1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101421265-A | Thiazole compounds as protein kinase b (pkb) inhibitors | AMGEN INC (US) | 2009-04-29 | — | — | CN | disclosed |