Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819383 | 0.77 | ALDH1A1 (0.44) | ALDH1A1TDP1CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL1178676 | 0.76 | CYP19A1 (0.39) | TRPA1CYP11B1CYP11B2 | |
| SCHEMBL12821930 | 0.73 | ALDH1A1 (0.41) | ALDH1A1TDP1CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL15202232 | 0.73 | ALDH1A1 (0.37) | ALDH1A1TDP1CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL5487137 | 0.73 | TRPA1 (0.40) | ALDH1A1TDP1TRPA1RXFP1TBXAS1 | |
| SCHEMBL23354136 | 0.73 | ALDH1A1 (0.37) | ALDH1A1TDP1CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL21879876 | 0.73 | ALDH1A1 (0.47) | ALDH1A1TDP1CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL1950890 | 0.73 | CYP11B1 (0.57) | ALDH1A1CYP11B1CYP11B2MAPTCYP3A4 | |
| SCHEMBL23930976 | 0.71 | ALDH1A1 (0.40) | ALDH1A1TDP1CYP11B1CYP11B2TBXAS1 | |
| SCHEMBL31518413 | 0.71 | ALDH1A1 (0.40) | ALDH1A1TDP1CYP11B1CYP11B2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101420942-B | Small-molecule modulators of TRP-P8 activity | DENDREON CORP | 2014-03-12 | — | — | CN | disclosed |
| CN-101420942-A | Small-molecule modulators of TRP-P8 activity | DENDREON CORP (US) | 2009-04-29 | — | — | CN | disclosed |