Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Carmoterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 16/20 | 0.63 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28360013 | 0.84 | CYP2C19 (0.64) | ADRB2ADRB1ADRB3DRD2CYP2C19 | |
| Hydrochloric Acid SCHEMBL30339888 | 0.84 | CYP2C19 (0.64) | ADRB2ADRB1ADRB3DRD2CYP2C19 | |
| Carmoterol SCHEMBL617717 | 0.78 | ADRB2 (1.00) | ADRB2ADRB1 | |
| Carmoterol SCHEMBL5990417 | 0.78 | ADRB2 (1.00) | ADRB2ADRB1 | |
| Carmoterol SCHEMBL11912044 | 0.78 | ADRB2 (1.00) | ADRB2ADRB1 | |
| Carmoterol SCHEMBL13619222 | 0.78 | ADRB2 (1.00) | ADRB2ADRB1 | |
| Carmoterol SCHEMBL10494358 | 0.78 | ADRB2 (1.00) | ADRB2ADRB1 | |
| Carmoterol SCHEMBL10494565 | 0.78 | ADRB2 (1.00) | ADRB2ADRB1 | |
| Carmoterol SCHEMBL465645 | 0.78 | ADRB2 (1.00) | ADRB2ADRB1 | |
| Carmoterol SCHEMBL594076 | 0.77 | ADRB2 (0.98) | ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101500577-A | Method and system for the delivery of corticosteroids having an enhanced pharmacokinetic profile | TIKA LAEKEMEDEL AB (SE) | 2009-08-05 | — | — | CN | disclosed |
| CN-101437520-A | Systems and methods for the delivery of corticosteroids having an increased lung deposition | VERUS PHARMACEUTICALS INC (SE) | 2009-05-20 | — | — | CN | disclosed |