Carmoterol

Carmoterol

SCHEMBL594076

COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)cc1.Cl

nearest known ligand 0.98

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB2

The experimentally established mechanism targets of Carmoterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ADRB2 known ✓ P07550 20/20 0.98
ADRB1 P08588 18/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Carmoterol SCHEMBL4360089 1.00 ADRB2 (0.98) ADRB2ADRB1
Carmoterol SCHEMBL29355060 1.00 ADRB2 (0.98) ADRB2ADRB1
Carmoterol SCHEMBL10494473 1.00 ADRB2 (0.98) ADRB2ADRB1
Carmoterol SCHEMBL364838 1.00 ADRB2 (0.98) ADRB2ADRB1
Carmoterol SCHEMBL10494299 1.00 ADRB2 (0.98) ADRB2ADRB1
Carmoterol SCHEMBL10494565 0.99 ADRB2 (1.00) ADRB2ADRB1
Carmoterol SCHEMBL11912044 0.99 ADRB2 (1.00) ADRB2ADRB1
Carmoterol SCHEMBL5990417 0.99 ADRB2 (1.00) ADRB2ADRB1
Carmoterol SCHEMBL465645 0.99 ADRB2 (1.00) ADRB2ADRB1
Carmoterol SCHEMBL10494358 0.99 ADRB2 (1.00) ADRB2ADRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 224 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190105404-A1 INHALANT FORMULATION CONTAINING SULFOALKYL ETHER CYCLODEXTRIN AND CORTICOSTEROID CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2019-04-11 US claimed
EP-3238708-A1 INHALANT FORMULATION CONTAINING CYCLODEXTRIN AND CORTICOSTEROID CyDex Pharmaceuticals, Inc. (US) 2017-11-01 EP claimed
EP-1732512-B1 INHALANT FORMULATION CONTAINING SULFOALKYL ETHER CYCLODEXTRIN AND CORTICOSTEROID CYDEX PHARMACEUTICALS INC (US) 2017-03-22 EP claimed
US-20090280067-A1 CRYSTAL FORM OF 8-HYDROXY-5-[(1R)-1-HYDROXY-2-[[(1R)-2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]ETHYL]-2(1H)-QUINOLINONE MONOHYDROCHLORIDE CHIESI FARMACEUTICI S.P.A. (IT) 2009-11-12 US claimed
US-20090280068-A1 POLYMORPH OF 8-HYDROXY-5-[(1R)-1-HYDROXY-2-[[(1R)-2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]ETHYL]-2(1H)-QUINOLINONE MONOHYDROCHLORIDE CHIESI FARMACEUTICI S.P.A. (IT) 2009-11-12 US claimed
EP-2116537-A1 Polymorph of 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone monohydrochloride CHIESI FARMACEUTICI S.p.A. (IT) 2009-11-11 EP claimed
EP-2116536-A1 Crystal form of 8-hydroxy-5-[(1r)-1-hydroxy-2-[[(1r)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1h)- quinolinone monohydrochloride CHIESI FARMACEUTICI S.p.A. (IT) 2009-11-11 EP claimed
US-20090263488-A1 PRESSURISED METERED DOSE INHALERS CONTAINING SOLUTIONS OF BETA-2 AGONISTS CHIESI FARMACEUTICI S.P.A. (IT) 2009-10-22 US claimed
EP-1732512-A4 INHALANT FORMULATION CONTAINING SULFOALKYL ETHER CYCLODEXTRIN AND CORTICOSTEROID CYDEX INC (US) 2008-07-23 EP claimed
EP-1729724-A4 INHALENT FORMULATION CONTAINING SULFOALKYL ETHER GAMMA-CYCLODEXTRYN AND CORTICOSTEROID CYDEX INC (US) 2008-07-23 EP claimed
US-20070020299-A1 Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid CYDEX PHARMACEUTICALS, INC. 2007-01-25 US claimed
US-20070020298-A1 Inhalant formulation containing sulfoalkyl ether gamma-cyclodextrin and corticosteroid CYDEX PHARMACEUTICALS, INC. 2007-01-25 US claimed
EP-1732512-A2 INHALANT FORMULATION CONTAINING SULFOALKYL ETHER CYCLODEXTRIN AND CORTICOSTEROID Cydex Inc. (US) 2006-12-20 EP claimed
EP-1729724-A1 INHALENT FORMULATION CONTAINING SULFOALKYL ETHER GAMMA-CYCLODEXTRYN AND CORTICOSTEROID Cydex Inc. (US) 2006-12-13 EP claimed
US-20060193785-A1 Pharmaceutical aerosol formulations for pressurized metered dose inhalers comprising a sequestering agent CHIESI FARMACEUTICI S.P.A. (IT) 2006-08-31 US claimed
WO-2005065435-A2 INHALANT FORMULATION CONTAINING SULFOALKYL ETHER CYCLODEXTRIN AND CORTICOSTEROID CYDEX, INC. ET AL. (US) 2005-07-21 WO claimed
WO-2005065649-A1 INHALANT FORMULATION CONTAINING SULFOALKYL ETHER Ϝ-CYCLODEXTRIN AND CORTICOSTEROID CYDEX, INC. (US) 2005-07-21 WO claimed
US-20050154013-A1 Pressurised metered dose inhalers containing solutions of beta-2 agonists CHIESI FARMACEUTICI S.P.A. (IT) 2005-07-14 US claimed
US-20040023935-A1 Inhalation compositions, methods of use thereof, and process for preparation of same DEY, L.P. 2004-02-05 US claimed
US-6624181-B1 Synergistic combination ALTANA PHARMA AG (DE) 2003-09-23 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090263488-A1 PRESSURISED METERED DOSE INHALERS CONTAINING SOLUTIONS OF BETA-2 AGONISTS ADRB2, ADRA2A, ADRA1D ADRB2 1/4885ADRB1 7/4885
US-20040023935-A1 Inhalation compositions, methods of use thereof, and process for preparation of same IL5, CHRM3, NOX5 ADRB2 19/4885ADRB1 24/4885
US-20090280067-A1 CRYSTAL FORM OF 8-HYDROXY-5-[(1R)-1-HYDROXY-2-[[(1R)-2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]ETHYL]-2(1H)-QUINOLINONE MONOHYDROCHLORIDE CYP8B1, HTR2C, HTR1D ADRB2 1408/4885ADRB1 1063/4885
US-20070020298-A1 Inhalant formulation containing sulfoalkyl ether gamma-cyclodextrin and corticosteroid STS, RORC, HSD11B1 ADRB2 443/4885ADRB1 250/4885
US-20190105404-A1 INHALANT FORMULATION CONTAINING SULFOALKYL ETHER CYCLODEXTRIN AND CORTICOSTEROID STS, SAE1, PDCD2L ADRB2 1076/4885ADRB1 805/4885
US-20070020299-A1 Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid STS, SAE1, PDCD2L ADRB2 1076/4885ADRB1 805/4885
US-20090280068-A1 POLYMORPH OF 8-HYDROXY-5-[(1R)-1-HYDROXY-2-[[(1R)-2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]ETHYL]-2(1H)-QUINOLINONE MONOHYDROCHLORIDE UGT1A8, HTR1D, UGT1A1 ADRB2 651/4885ADRB1 492/4885
US-20060193785-A1 Pharmaceutical aerosol formulations for pressurized metered dose inhalers comprising a sequestering agent HSD17B7, HSD17B1, CYP17A1 ADRB2 169/4885ADRB1 143/4885
US-20050154013-A1 Pressurised metered dose inhalers containing solutions of beta-2 agonists ADRB2, ADRA2A, ADRA1D ADRB2 1/4885ADRB1 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.