Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28261507 | 0.81 | MAPK1 (0.33) | KMT2AMEN1MAPTMAPK1MGLL | |
| SCHEMBL28165369 | 0.80 | CHKA (0.39) | MAPTNPSR1TDP1LMNA | |
| SCHEMBL2362320 | 0.80 | MAPT (0.35) | KMT2AMEN1GAAMAPTMAPK1 | |
| SCHEMBL27457816 | 0.79 | MEN1 (0.41) | KMT2AMEN1KDM4EALDH1A1NPC1 | |
| SCHEMBL27914491 | 0.78 | TSHR (0.40) | KMT2AMEN1MAPK1MGLLALDH1A1 | |
| SCHEMBL2115712 | 0.77 | — | — | |
| SCHEMBL27974239 | 0.77 | — | — | |
| SCHEMBL28249904 | 0.77 | KIF11 (0.37) | MAPTTDP1CA12CA2CYP3A4 | |
| SCHEMBL4576927 | 0.74 | — | — | |
| SCHEMBL27039521 | 0.74 | ADRB2 (0.51) | KDM4EALDH1A1LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101486711-B | 2,3-diaryl pyrimidine [1,2-a]benzimidazole heterocyclic compound, preparation and use thereof | UNIV SHANXI NORMAL | 2011-07-06 | — | — | CN | disclosed |
| CN-101506175-A | 2-anilino-4-(heterocyclic)amino-pyrimidines as inhibitors of protein kinase C-alpha | BOEHRINGER INGELHEIM INT (DE) | 2009-08-12 | — | — | CN | disclosed |
| CN-101486711-A | 2,3-diaryl pyrimidine [1,2-a]benzimidazole heterocyclic compound, preparation and use thereof | UNIV SHANXI NORMAL (CN) | 2009-07-22 | — | — | CN | disclosed |