Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.67 |
| ▸ | MAOB | P27338 | 15/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6832862 | 0.90 | ALDH1A1 (0.56) | GRM5MAOBMAOAALDH1A1SMN1; SMN2 | |
| SCHEMBL29196216 | 0.85 | GRM5 (0.67) | GRM5MAOBMAOAALDH1A1SMN1; SMN2 | |
| SCHEMBL4483341 | 0.85 | MAPT (0.66) | GRM5MAOBMAOAALDH1A1SMN1; SMN2 | |
| SCHEMBL27762328 | 0.85 | GRM5 (0.63) | GRM5MAOBMAOAALDH1A1SMN1; SMN2 | |
| SCHEMBL20179643 | 0.85 | GRM5 (0.63) | GRM5MAOBMAOAALDH1A1SMN1; SMN2 | |
| SCHEMBL67621 | 0.81 | MAOB (0.60) | GRM5MAOBMAOAALDH1A1SMN1; SMN2 | |
| Alcohol SCHEMBL8562852 | 0.81 | GRM5 (0.59) | GRM5MAOBMAOAALDH1A1SMN1; SMN2 | |
| Cyclopropane SCHEMBL28516873 | 0.80 | MAOB (0.59) | GRM5MAOBMAOAALDH1A1SMN1; SMN2 | |
| SCHEMBL6266662 | 0.80 | CA2 (0.61) | GRM5ALDH1A1SMN1; SMN2NPC1HPGD | |
| SCHEMBL3876644 | 0.79 | KMT2A (0.62) | ALDH1A1SMN1; SMN2NPC1NFKB1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541757-A | Pyrazolines as Mineralocorticoid Receptor Antagonists | PFIZER PROD INC (US) | 2009-09-23 | — | — | CN | disclosed |