SCHEMBL2776296

SCHEMBL2776296

O=C(O)c1nn(-c2ccc(Cl)cc2Cl)c2c1Cc1cc(Br)sc1-2

nearest known ligand 0.48

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ CNR2 P34972 6/20 0.45
▸ CNR1 P21554 3/20 0.44
▸ TDP1 Q9NUW8 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL495966 0.90 CNR2 (0.52) CNR2CNR1
SCHEMBL496034 0.88 CNR2 (0.49) CNR2CNR1TDP1
SCHEMBL2771955 0.86 KDM4E (0.49) CNR2CNR1TDP1
SCHEMBL16162158 0.83 CNR2 (0.46) CNR2CNR1TDP1
SCHEMBL496341 0.82 CNR2 (0.46) CNR2CNR1
SCHEMBL2774194 0.81 L3MBTL1 (0.39) CNR2CNR1
SCHEMBL495902 0.81 CNR2 (0.49) CNR2CNR1
SCHEMBL495876 0.79 CNR2 (0.50) CNR2CNR1
SCHEMBL496843 0.79 CNR2 (0.53) CNR2CNR1
SCHEMBL16168863 0.79 CNR2 (0.47) CNR2CNR1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2230243-A1 Pharmaceutical compounds Neuroscienze Pharmaness S.C. A R.L. (IT) 2010-09-22 — — EP disclosed
EP-2230243-A1 Pharmaceutical compounds Neuroscienze Pharmaness S.C. A R.L. (IT) 2010-09-22 — — EP disclosed
US-20100215759-A1 PHARMACEUTICAL COMPOUNDS NEUROSCIENZE PHARMANESS S.C.A.R.L. (IT) 2010-08-26 — — US disclosed
US-20100215759-A1 PHARMACEUTICAL COMPOUNDS NEUROSCIENZE PHARMANESS S.C.A.R.L. (IT) 2010-08-26 — — US disclosed
US-20100215759-A1 PHARMACEUTICAL COMPOUNDS NEUROSCIENZE PHARMANESS S.C.A.R.L. (IT) 2010-08-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100215759-A1 PHARMACEUTICAL COMPOUNDS CNR2, CNR1, OPRK1 CNR2 1/4885CNR1 2/4885TDP1 4508/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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