Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 2/20 | 0.39 |
| ▸ | CDK8 | P49336 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27784855 | 0.81 | SIGMAR1 (0.58) | SIGMAR1POLBUSP2ALDH1A1TSHR | |
| SCHEMBL27763340 | 0.79 | SIGMAR1 (0.55) | SIGMAR1POLBUSP2ALDH1A1TSHR | |
| SCHEMBL27784857 | 0.77 | SIGMAR1 (0.53) | SIGMAR1POLBUSP2ALDH1A1TSHR | |
| SCHEMBL27318407 | 0.76 | SIGMAR1 (0.60) | SIGMAR1POLBUSP2ALDH1A1TSHR | |
| Benzamide SCHEMBL1474746 | 0.75 | SIGMAR1 (0.58) | SIGMAR1POLBUSP2ALDH1A1TSHR | |
| SCHEMBL8937583 | 0.75 | SIGMAR1 (0.49) | SIGMAR1ALDH1A1RXFP1HRH4HTR6 | |
| SCHEMBL28393 | 0.74 | SIGMAR1 (1.00) | SIGMAR1POLBUSP2ALDH1A1TSHR | |
| SCHEMBL894920 | 0.74 | SIGMAR1 (1.00) | SIGMAR1POLBUSP2ALDH1A1TSHR | |
| SCHEMBL13899801 | 0.74 | SIGMAR1 (0.62) | SIGMAR1POLBUSP2ALDH1A1TSHR | |
| SCHEMBL3999141 | 0.74 | SIGMAR1 (0.62) | SIGMAR1POLBUSP2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101591311-A | 1-(3-phenyl acryloyl) bridged piperazine derivatives and preparation method thereof | UNIV HEBEI TECHNOLOGY (CN) | 2009-12-02 | — | — | CN | claimed |
| CN-101591311-A | 1-(3-phenyl acryloyl) bridged piperazine derivatives and preparation method thereof | UNIV HEBEI TECHNOLOGY (CN) | 2009-12-02 | — | — | CN | disclosed |