Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | CCNC | P24863 | 2/20 | 0.58 |
| ▸ | CDK8 | P49336 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.56 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.56 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.56 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL894920 | 1.00 | SIGMAR1 (1.00) | SIGMAR1HPGDRXFP1CCNCCDK8 | |
| Piperazine SCHEMBL28228981 | 0.98 | SIGMAR1 (0.96) | SIGMAR1HPGDRXFP1CCNCCDK8 | |
| Hydrochloric Acid SCHEMBL1597474 | 0.98 | SIGMAR1 (0.96) | SIGMAR1HPGDRXFP1CCNCCDK8 | |
| SCHEMBL9644712 | 0.98 | SIGMAR1 (0.96) | SIGMAR1HPGDRXFP1CCNCCDK8 | |
| Piperazine SCHEMBL27760905 | 0.96 | SIGMAR1 (0.93) | SIGMAR1HPGDRXFP1CCNCCDK8 | |
| Formic Acid SCHEMBL7986200 | 0.93 | SIGMAR1 (0.86) | SIGMAR1HPGDRXFP1CCNCCDK8 | |
| SCHEMBL3423662 | 0.93 | SIGMAR1 (0.86) | SIGMAR1HPGDRXFP1CCNCCDK8 | |
| SCHEMBL12344755 | 0.91 | SIGMAR1 (0.83) | SIGMAR1HPGDRXFP1CCNCCDK8 | |
| Nitric Acid SCHEMBL14695754 | 0.90 | SIGMAR1 (0.81) | SIGMAR1HPGDRXFP1CCNCCDK8 | |
| Pyridine SCHEMBL28123146 | 0.90 | SIGMAR1 (0.81) | SIGMAR1HPGDRXFP1CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1789 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118684644-A | Eupatilin derivative containing piperazine structure and preparation method and application thereof | 南阳医学高等专科学校 | 2024-09-24 | — | — | CN | claimed |
| CN-118324717-A | Substituted benzoyl piperazine compound and application thereof in preparation of medicines for resisting chikungunya virus | 中国人民解放军海军军医大学 | 2024-07-12 | — | — | CN | claimed |
| CN-115417834-B | Substituted benzoyl piperazine compound and application thereof in preparation of medicines for resisting chikungunya virus | 中国人民解放军海军军医大学 | 2024-06-11 | — | — | CN | claimed |
| CN-115368320-B | Substituted benzoyl piperazine compound and application thereof | 中国人民解放军海军军医大学 | 2024-05-31 | — | — | CN | claimed |
| CN-116444454-B | N-hydroxy amidine derivative, preparation method and application thereof, and tumor immunotherapy medicament | 中国医学科学院医药生物技术研究所 | 2023-09-12 | — | — | CN | claimed |
| CN-116444454-A | N-hydroxy amidine derivative, preparation method and application thereof, and tumor immunotherapy medicament | 中国医学科学院医药生物技术研究所 | 2023-07-18 | — | — | CN | claimed |
| CN-115677812-A | Tripterine derivatives, and preparation method and application thereof | 聊城大学 | 2023-02-03 | — | — | CN | claimed |
| US-20230010299-A1 | HETEROCYCLIC TRPML1 AGONISTS | LIBRA THERAPEUTICS, INC. | 2023-01-12 | — | — | US | claimed |
| CN-112300094-B | Substituted benzoyl piperazine compounds and application thereof in preparation of anti-chikungunya virus medicines | 中国人民解放军海军军医大学 | 2022-12-16 | — | — | CN | claimed |
| CN-115417834-A | Substituted benzoyl piperazine compounds and application thereof in preparing anti-chikungunya virus medicines | 中国人民解放军海军军医大学 | 2022-12-02 | — | — | CN | claimed |
| US-4614739-A | Oxindole derivatives, pharmaceutical compositions and use | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-09-30 | — | — | US | claimed |
| US-4497808-A | N-Oxide compounds useful in the treatment of cardiovascular ailments | CIBA-GEIGY CORPORATION (US) | 1985-02-05 | — | — | US | claimed |
| EP-0130779-A2 | Pharmaceutical composition suitable for intestinal administration | KOWA COMPANY, LTD. (JP) | 1985-01-09 | — | — | EP | claimed |
| EP-0062887-B1 | INDOLINONE-2 DERIVATIVES, PROCESS FOR THEIR PREPARATION AND NEURO-ANABOLIC MEDIUMS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-07-11 | — | — | EP | claimed |
| EP-0111453-A1 | Amide derivatives | CIBA-GEIGY AG (CH) | 1984-06-20 | — | — | EP | claimed |
| EP-0111455-A2 | Unsaturated lactones | CIBA-GEIGY AG (CH) | 1984-06-20 | — | — | EP | claimed |
| EP-0083315-A2 | Pyridyl-N-oxides, processes for their preparation and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1983-07-06 | — | — | EP | claimed |
| EP-0062887-A1 | Indolinone-2 derivatives, process for their preparation and neuro-anabolic mediums containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-10-20 | — | — | EP | claimed |
| US-4072712-A | FROM ISOCYANATES, CATALYSIS | BAYER AKTIENGESELLSCHAFT (DT) | 1978-02-07 | — | — | US | claimed |
| US-3939268-A | 2,4-Diamino substituted pyridol(3,2-d)pyrimidine as antithrombotic agents | BOEHRINGER INGELHEIM GMBH (DT) | 1976-02-17 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230010299-A1 | HETEROCYCLIC TRPML1 AGONISTS | TRPM7, TRPM2, TRPM5 | SIGMAR1 1483/4885HPGD 1133/4885RXFP1 1091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.