Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Wogonin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.80 |
| ▸ | GABRP | O00591 | 1/20 | 0.80 |
| ▸ | GABRD | O14764 | 1/20 | 0.80 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.80 |
| ▸ | PKM | P14618 | 1/20 | 0.80 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.80 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.80 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.80 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.80 |
| ▸ | CCNC | P24863 | 1/20 | 0.80 |
| ▸ | CDK2 | P24941 | 1/20 | 0.80 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.80 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.80 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.80 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.80 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.80 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.80 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.80 |
| ▸ | CDK8 | P49336 | 1/20 | 0.80 |
| ▸ | CDK7 | P50613 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Wogonin SCHEMBL29632729 | 0.90 | GABRP (1.00) | KDM1AGABRPGABRDCCNT1PKM | |
| Wogonin SCHEMBL139083 | 0.90 | GABRP (1.00) | KDM1AGABRPGABRDCCNT1PKM | |
| Wogonin SCHEMBL27763352 | 0.89 | GABRP (0.93) | KDM1AGABRPGABRDCCNT1PKM | |
| Wogonin SCHEMBL29030574 | 0.89 | GABRP (0.97) | KDM1AGABRPGABRDCCNT1PKM | |
| Wogonin SCHEMBL28516605 | 0.89 | GABRP (0.97) | KDM1AGABRPGABRDCCNT1PKM | |
| Wogonin SCHEMBL27921406 | 0.89 | GABRP (0.97) | KDM1AGABRPGABRDCCNT1PKM | |
| Wogonin SCHEMBL29025251 | 0.89 | GABRP (0.97) | KDM1AGABRPGABRDCCNT1PKM | |
| Wogonin SCHEMBL27893807 | 0.85 | KDM1A (0.90) | KDM1AGABRPGABRDCCNT1PKM | |
| Wogonin SCHEMBL27785209 | 0.80 | CCNT1 (0.80) | KDM1AGABRPGABRDCCNT1PKM | |
| Moslosooflavone SCHEMBL6070206 | 0.80 | ACHE (1.00) | KDM1AGABRPGABRDCCNT1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101591322-B | Cyclin dependent kinases inhibitor scutellaria flavonoid organic amine derivatives, preparation method and application thereof | UNIV DALIAN TECH | 2013-08-21 | — | — | CN | disclosed |
| CN-101591322-A | Cyclin dependent kinases inhibitor scutellaria flavonoid organic amine derivatives and method for making thereof and purposes | UNIV DALIAN TECH (CN) | 2009-12-02 | — | — | CN | disclosed |