Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | TDO2 | P48775 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2837168 | 0.85 | EGFR (0.56) | EGFRMAPK1SYKGRM1BRAF | |
| SCHEMBL5572683 | 0.83 | DDX3X (0.68) | MEN1MAPTKMT2ALMNAALDH1A1 | |
| SCHEMBL7554636 | 0.82 | SOS1 (0.60) | MEN1MAPTKMT2ATDP1SOS1 | |
| SCHEMBL2127990 | 0.79 | MAPT (0.86) | MEN1MAPTKMT2AKDM4ELMNA | |
| SCHEMBL3080763 | 0.78 | MAPT (0.70) | MEN1MAPTKMT2AKDM4ELMNA | |
| Hydrochloric Acid SCHEMBL21647359 | 0.77 | MAPT (0.82) | MEN1MAPTKMT2AKDM4ELMNA | |
| Hydrochloric Acid SCHEMBL31528395 | 0.77 | MAPT (0.82) | MEN1MAPTKMT2AKDM4ELMNA | |
| SCHEMBL24004080 | 0.76 | KDM4E (0.67) | MEN1MAPTKMT2AKDM4ELMNA | |
| SCHEMBL9480199 | 0.75 | MAPT (0.95) | MEN1MAPTKMT2AKDM4ELMNA | |
| SCHEMBL670295 | 0.75 | MEN1 (0.57) | MEN1MAPTKMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101454287-A | Substituted cyanopyridines as protein kinase inhibitors | WYETH CORP (US) | 2009-06-10 | — | — | CN | claimed |
| CN-101454287-A | Substituted cyanopyridines as protein kinase inhibitors | WYETH CORP (US) | 2009-06-10 | — | — | CN | disclosed |