SCHEMBL670295

SCHEMBL670295

NNc1ccc(F)c(Cl)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.57
KMT2A Q03164 4/20 0.57
MAPT P10636 4/20 0.57
HTT P42858 3/20 0.57
ALDH1A1 P00352 2/20 0.57
NPSR1 Q6W5P4 1/20 0.57
SLC2A1 P11166 1/20 0.52
SOS1 Q07889 1/20 0.51
RAPGEF4 Q8WZA2 1/20 0.50
TSHR P16473 2/20 0.49
PLA2G1B P04054 1/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
ATG4B Q9Y4P1 1/20 0.49
MAPK1 P28482 1/20 0.47
NPC1 O15118 3/20 0.47
RAB9A P51151 3/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1160446 0.98 MEN1 (0.55) MEN1KMT2AMAPTHTTALDH1A1
Hydrochloric Acid SCHEMBL25252460 0.98 MEN1 (0.55) MEN1KMT2AMAPTHTTALDH1A1
SCHEMBL15076832 0.82 MAPT (0.50) MEN1KMT2AMAPTHTTALDH1A1
Tert-Butyl Formate SCHEMBL28113606 0.80 HTT (0.47) MEN1KMT2AMAPTHTTALDH1A1
Hydrochloric Acid SCHEMBL2171244 0.80 RAPGEF4 (0.49) MEN1KMT2AMAPTHTTALDH1A1
Hydrochloric Acid SCHEMBL29418041 0.80 RAPGEF4 (0.49) MEN1KMT2AMAPTHTTALDH1A1
SCHEMBL833283 0.78 MAPT (0.55) MEN1KMT2AMAPTHTTRAPGEF4
SCHEMBL1143594 0.78 SOS1 (0.47) MEN1KMT2AMAPTALDH1A1SOS1
SCHEMBL29502263 0.78 MAPT (0.55) MEN1KMT2AMAPTHTTRAPGEF4
SCHEMBL19868628 0.77 MEN1 (0.57) MEN1KMT2AMAPTHTTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 271 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE50878-E1 Pyrazolo pyridine derivatives as NADPH oxidase inhibitors CALLIDITAS THERAPEUTICS SUISSE SA (CH) 2026-05-05 US disclosed
US-12227482-B2 Compounds and compositions for the treatment of cancer THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-02-18 US disclosed
EP-4339192-A2 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER The Regents of the University of California (US) 2024-03-20 EP disclosed
EP-3962909-B1 NOVEL OXALYL PIPERAZINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) AICURIS GMBH & CO KG (DE) 2023-10-04 EP disclosed
EP-3962909-B1 NOVEL OXALYL PIPERAZINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) AICURIS GMBH & CO KG (DE) 2023-10-04 EP disclosed
EP-3478284-B1 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER UNIV CALIFORNIA (US) 2023-10-04 EP disclosed
US-20230150942-A1 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2023-05-18 US disclosed
US-20230145822-A1 SMALL MOLECULES INDUCING THE DEGRADATION OF THE CELLULAR PRION PROTEIN FONDAZIONE TELETHON (IT) 2023-05-11 US disclosed
EP-4126225-A1 SMALL MOLECULES INDUCING THE DEGRADATION OF THE CELLULAR PRION PROTEIN Istituto Nazionale di Fisica Nucleare (IT) 2023-02-08 EP disclosed
US-11560356-B2 Compounds and compositions for the treatment of cancer THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-01-24 US disclosed
EP-1124804-A1 PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS ABBOTT LABORATORIES (US) 2001-08-22 EP disclosed
US-6277877-B1 GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS PFIZER, INC. 2001-08-21 US disclosed
EP-1102753-A2 PYRAZOLES AS ESTROGEN RECEPTOR MODULATORS CHIRON CORPORATION (US) 2001-05-30 EP disclosed
CN-1277605-A Arylpyridazinones as prostaglandin endoperoxide H synthase biosynthesis inhibitors ABBOTT LAB (US) 2000-12-20 CN disclosed
US-6107329-A HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS PFIZER, INC. (US) 2000-08-22 US disclosed
WO-2000024719-A1 PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS ABBOTT LABORATORIES (US) 2000-05-04 WO disclosed
WO-2000007996-A2 PYRAZOLES AS ESTROGEN RECEPTOR MODULATORS CHIRON CORPORATION (US) 2000-02-17 WO disclosed
EP-0832065-A1 SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS PFIZER INC. (US) 1998-04-01 EP disclosed
WO-1996039384-A1 SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS PFIZER, INC. (US) 1996-12-12 WO disclosed
US-4358611-A FROM A PHENYLHYDRAZINE, A CHLOROFORMATE, PHOSGENE AND A SECONDARY AMINE SHELL OIL COMPANY (US) 1982-11-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230150942-A1 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER TP53, HCCS, CFTR MEN1 2652/4885KMT2A 3811/4885MAPT 4548/4885
US-11560356-B2 Compounds and compositions for the treatment of cancer TP53, HCCS, CFTR MEN1 2652/4885KMT2A 3811/4885MAPT 4548/4885
US-12227482-B2 Compounds and compositions for the treatment of cancer TP53, HCCS, CFTR MEN1 2652/4885KMT2A 3811/4885MAPT 4548/4885
US-20230145822-A1 SMALL MOLECULES INDUCING THE DEGRADATION OF THE CELLULAR PRION PROTEIN PRNP, PPIE, PPIC MEN1 3669/4885KMT2A 4350/4885MAPT 147/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.