Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 0.86 |
| ▸ | MEN1 | O00255 | 4/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.80 |
| ▸ | HBB | P68871 | 2/20 | 0.80 |
| ▸ | DDX5 | P17844 | 1/20 | 0.80 |
| ▸ | CASP1 | P29466 | 1/20 | 0.80 |
| ▸ | CASP7 | P55210 | 1/20 | 0.80 |
| ▸ | GLA | P06280 | 3/20 | 0.77 |
| ▸ | TP53 | P04637 | 2/20 | 0.77 |
| ▸ | HPGD | P15428 | 2/20 | 0.77 |
| ▸ | STAT6 | P42226 | 1/20 | 0.77 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.77 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.77 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.77 |
| ▸ | GMNN | O75496 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3513607 | 1.00 | TOP1 (0.86) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL23929259 | 0.93 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL16649109 | 0.93 | TOP1 (0.78) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL23963902 | 0.93 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL16649363 | 0.91 | TOP1 (0.79) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3138027 | 0.90 | TOP1 (0.82) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL18251453 | 0.90 | TOP1 (0.73) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydroxycamptothecin SCHEMBL25875 | 0.89 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydroxycamptothecin SCHEMBL29350707 | 0.89 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| Hydroxycamptothecin SCHEMBL29929278 | 0.89 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104650342-B | Highly branched chain polymeric drug precursor and its application | 江苏豪森药业集团有限公司 | 2018-07-10 | — | — | CN | disclosed |
| CN-104650342-A | Highly-branched polymerized prodrug, and applications thereof | JIANGSU HANSOH PHARMACEUTICAL | 2015-05-27 | — | — | CN | disclosed |
| CN-101605539-B | Treatment of resistant or refractory cancers with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin | ENZON PHARMACEUTICALS INC US | 2013-01-02 | — | — | CN | disclosed |
| CN-102481364-A | Methods of treating HER2 positive cancers with HER2 receptor antagonists in combination with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin | ENZON PHARMACEUTICALS INC | 2012-05-30 | — | — | CN | disclosed |
| CN-101605539-A | Multi-arm polymeric conjugate treatment repellence or refractory cancers with 7-ethyl-10-hydroxycamptothecine | ENZON PHARMACEUTICALS INC (US) | 2009-12-16 | — | — | CN | disclosed |
| CN-101420963-A | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers | ENZON PHARMACEUTICALS INC (US) | 2009-04-29 | — | — | CN | disclosed |