Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27766001 | 0.80 | GPR119 (0.39) | LMNASMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL27666917 | 0.79 | MEN1 (0.44) | ALDH1A1LMNAMEN1KMT2AHPGD | |
| SCHEMBL475285 | 0.79 | NPC1 (0.41) | MAPTLMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL28993218 | 0.79 | KDM4E (0.38) | ALDH1A1SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL3339817 | 0.78 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL31532161 | 0.77 | MAPT (0.47) | MAPTALDH1A1LMNASMN1; SMN2ALOX5 | |
| SCHEMBL312821 | 0.77 | MAPT (0.47) | MAPTALDH1A1LMNASMN1; SMN2ALOX5 | |
| SCHEMBL29540947 | 0.76 | MAPT (0.46) | MAPTALDH1A1LMNASMN1; SMN2ALOX5 | |
| SCHEMBL5446082 | 0.76 | MAPT (0.46) | MAPTALDH1A1LMNASMN1; SMN2ALOX5 | |
| SCHEMBL27765914 | 0.76 | NR1H2 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101472912-A | Pyridine and pyrazine derivatives as MNK kinase inhibitors | BIOVITRUM AB PUBL (SE) | 2009-07-01 | — | — | CN | disclosed |