Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.32 |
| ▸ | OGG1 | O15527 | 1/20 | 0.32 |
| ▸ | EDNRB | P24530 | 3/20 | 0.31 |
| ▸ | EDNRA | P25101 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.31 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.31 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.31 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MC4R | P32245 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4884756 | 0.79 | CYP11B1 (0.35) | NPSR1CYP11B1CYP11B2MAPK1HSD17B10 | |
| SCHEMBL1423935 | 0.76 | CYP11B1 (0.33) | NPSR1CYP11B1CYP11B2GRM5 | |
| SCHEMBL8548870 | 0.76 | NPSR1 (0.33) | NPSR1CYP11B1CYP11B2GRM5 | |
| SCHEMBL20843903 | 0.74 | — | — | |
| SCHEMBL5326782 | 0.72 | BRD4 (0.32) | MEN1KMT2ANPSR1CYP11B1CYP11B2 | |
| SCHEMBL5447440 | 0.72 | CYP19A1 (0.36) | SMN1; SMN2MEN1OPRM1OPRD1KMT2A | |
| SCHEMBL9408078 | 0.67 | ALDH1A1 (0.36) | SMN1; SMN2MEN1OPRM1OPRD1KMT2A | |
| SCHEMBL27761432 | 0.66 | CYP11B1 (0.31) | CYP11B1CYP11B2ACSS2POLBNQO2 | |
| SCHEMBL3500675 | 0.66 | CYP11B1 (0.33) | NPSR1CYP11B1CYP11B2 | |
| SCHEMBL6197960 | 0.64 | KDM4E (0.45) | SMN1; SMN2MEN1KMT2ANPSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101568542-B | 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives | ACTELION PHARMACEUTICALS LTD | 2013-03-27 | — | — | CN | disclosed |
| CN-101568542-A | 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives | ACTELION PHARMACEUTICALS LTD (CH) | 2009-10-28 | — | — | CN | disclosed |