Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4884756 | 0.81 | CYP11B1 (0.35) | NPSR1CYP11B1CYP11B2GRM5ADORA2A | |
| SCHEMBL1423935 | 0.79 | CYP11B1 (0.33) | NPSR1CYP11B1CYP11B2GRM5ADORA2A | |
| SCHEMBL27766643 | 0.76 | SMN1; SMN2 (0.33) | NPSR1CYP11B1CYP11B2GRM5 | |
| SCHEMBL5326782 | 0.75 | BRD4 (0.32) | NPSR1CYP11B1CYP11B2ADORA3 | |
| SCHEMBL5447440 | 0.75 | CYP19A1 (0.36) | NPSR1CYP11B1CYP11B2ADORA3TSHR | |
| SCHEMBL9408078 | 0.69 | ALDH1A1 (0.36) | NPSR1CYP11B1CYP11B2ADORA2AADORA3 | |
| SCHEMBL3500675 | 0.68 | CYP11B1 (0.33) | NPSR1CYP11B1CYP11B2 | |
| SCHEMBL10913496 | 0.68 | CYP11B1 (0.33) | CYP11B1CYP11B2ADORA3TSHR | |
| SCHEMBL2720194 | 0.67 | NPC1 (0.34) | — | |
| SCHEMBL5240188 | 0.67 | CYP11B1 (0.43) | NPSR1CYP11B1CYP11B2ADORA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0514198-B1 | 1H-Imidazol-1-yl-methyl benzofuran derivatives with the imidazolyl moiety being substituted by a cycloalkyl group | GLAXO GROUP LTD (GB) | 1998-08-05 | — | — | EP | disclosed |
| US-5498722-A | HYPOTENSIVES | GLAXO GROUP (GB) | 1996-03-12 | — | — | US | disclosed |
| US-5332831-A | Angiotensin antagonist | GLAXO GROUP LIMITED (GB) | 1994-07-26 | — | — | US | disclosed |
| WO-1992020674-A1 | 1H-IMIDAZOL-1-YL-METHYL BENZOFURAN DERIVATIVES, WITH THE IMIDAZOLYL MOIETY BEING SUBSTITUTED BY A CYCLOALKYL GROUP | GLAXO GROUP LIMITED (GB) | 1992-11-26 | — | — | WO | disclosed |
| EP-0514198-A1 | 1H-Imidazol-1-yl-methyl benzofuran derivatives with the imidazolyl moiety being substituted by a cycloalkyl group | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |