Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27788556 | 0.86 | KDM4C (0.39) | CYP11B2KDM4CIDO1TRPV1GCGR | |
| SCHEMBL27767008 | 0.76 | CYP17A1 (0.40) | CYP17A1CYP11B2CYP19A1CYP11B1HRH1 | |
| SCHEMBL2817696 | 0.76 | CYP17A1 (0.40) | CYP17A1CYP11B2NPY5RCYP19A1CYP11B1 | |
| SCHEMBL4077603 | 0.67 | FFAR1 (0.60) | — | |
| SCHEMBL27788561 | 0.65 | IDO1 (0.36) | CYP11B2KDM4CIDO1 | |
| SCHEMBL8865733 | 0.65 | CYP11B1 (0.62) | CYP11B2CYP11B1 | |
| SCHEMBL1337775 | 0.64 | PIN1 (0.50) | MAPK1KDM4CTRPV1KDM5AKDM5B | |
| SCHEMBL1340548 | 0.64 | PIN1 (0.50) | MAPK1KDM4CTRPV1KDM5AKDM5B | |
| SCHEMBL1340154 | 0.64 | PIN1 (0.50) | MAPK1KDM4CTRPV1KDM5AKDM5B | |
| SCHEMBL27788555 | 0.63 | SRD5A1 (0.37) | CYP11B2CYP11B1KDM4CTRPV1KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101605777-A | Imidazoles as aldosterone synthase inhibitors | NOVARTIS AG (CH) | 2009-12-16 | — | — | CN | disclosed |