Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 10/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL59811 | 0.87 | ACVRL1 (0.48) | ACVRL1PIK3CDNTRK1NTRK2 | |
| SCHEMBL16021414 | 0.85 | ACVRL1 (0.50) | ACVRL1PIK3CDNTRK1NTRK2 | |
| SCHEMBL5076725 | 0.85 | ACVRL1 (0.49) | ACVRL1PIK3CDNTRK1NTRK2 | |
| SCHEMBL59980 | 0.85 | ACVRL1 (0.63) | ACVRL1PIK3CD | |
| SCHEMBL14700063 | 0.85 | ACVRL1 (0.47) | ACVRL1PIK3CDNTRK1NTRK2 | |
| SCHEMBL5136418 | 0.84 | ACVRL1 (0.64) | ACVRL1PIK3CD | |
| SCHEMBL59716 | 0.82 | ACVRL1 (0.52) | ACVRL1PIK3CDCSNK2A2CSNK2A1 | |
| SCHEMBL16011258 | 0.82 | ACVRL1 (0.59) | ACVRL1PIK3CD | |
| SCHEMBL27747182 | 0.79 | ACVRL1 (0.65) | ACVRL1PIK3CD | |
| SCHEMBL5077805 | 0.79 | ACVRL1 (0.44) | ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101466710-B | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC | 2013-05-29 | — | — | CN | disclosed |
| CN-101466710-A | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2009-06-24 | — | — | CN | disclosed |