Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.51 |
| ▸ | RAB9A | P51151 | 7/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8840161 | 0.88 | NPC1 (0.51) | NPC1RAB9AHDAC6SMN1; SMN2KDM4E | |
| SCHEMBL20486119 | 0.86 | NPC1 (0.54) | NPC1RAB9AHDAC6SMN1; SMN2KDM4E | |
| SCHEMBL191761 | 0.85 | NPC1 (0.49) | NPC1RAB9AHDAC6SMN1; SMN2KDM4E | |
| SCHEMBL11233145 | 0.85 | NPC1 (0.49) | NPC1RAB9AHDAC6SMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL3691522 | 0.83 | NPC1 (0.48) | NPC1RAB9AHDAC6SMN1; SMN2KDM4E | |
| SCHEMBL27768553 | 0.82 | MAPK8 (0.54) | NPC1RAB9ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL11231009 | 0.82 | RAB9A (0.46) | NPC1RAB9AHDAC6SMN1; SMN2KDM4E | |
| SCHEMBL2427077 | 0.80 | HDAC6 (0.46) | NPC1RAB9AHDAC6SMN1; SMN2KDM4E | |
| SCHEMBL2423066 | 0.80 | NPC1 (0.49) | NPC1RAB9AHDAC6SMN1; SMN2KDM4E | |
| SCHEMBL2426380 | 0.80 | TRPM8 (0.55) | NPC1RAB9AHDAC6SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102850324-A | Indole compounds | MICROBIA INC | 2013-01-02 | — | — | CN | disclosed |
| CN-101563337-A | Indole compounds | MICROBIA INC (US) | 2009-10-21 | — | — | CN | disclosed |