Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | CRHBP | P24387 | 1/20 | 0.58 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.58 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.45 |
| ▸ | FBP1 | P09467 | 1/20 | 0.44 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 4/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.44 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31863830 | 0.87 | CRHBP (0.54) | TSHRCRHBPCRHR2ABCB1ABCC1 | |
| SCHEMBL3956703 | 0.87 | CRHBP (0.54) | TSHRCRHBPCRHR2ABCB1ABCC1 | |
| SCHEMBL27786187 | 0.81 | PTPN1 (0.58) | DHODHPTPN1AKR1C2AKR1C1AKR1C3 | |
| SCHEMBL28002286 | 0.80 | TSHR (0.58) | TSHRTDP1L3MBTL1 | |
| SCHEMBL5193454 | 0.79 | CRHBP (0.59) | TSHRCRHBPCRHR2ABCB1ABCC1 | |
| SCHEMBL27985266 | 0.79 | DTYMK (0.58) | TSHRCRHBPCRHR2ABCB1ABCC1 | |
| SCHEMBL6830067 | 0.78 | TSHR (0.59) | TSHRTDP1L3MBTL1 | |
| SCHEMBL28781440 | 0.78 | PTGS1 (0.62) | TSHRCRHBPCRHR2ABCB1ABCC1 | |
| SCHEMBL6837874 | 0.77 | CRHBP (0.71) | CRHBPCRHR2ABCB1ABCC1PTPN1 | |
| SCHEMBL13280610 | 0.77 | TSHR (0.57) | TSHRAKR1C2AKR1C1AKR1C3AKR1C4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102438989-B | Novel oxazolone and pyrrolidinone-substituted arylamides | HOFFMANN LA ROCHE | 2015-05-27 | — | — | CN | disclosed |
| CN-103159692-B | Tetrazole-substituted arylamides | HOFFMANN LA ROCHE | 2015-03-18 | — | — | CN | disclosed |
| CN-102574778-B | Novel biphenyl and phenyl-pyridine amides | HOFFMANN LA ROCHE | 2015-01-07 | — | — | CN | disclosed |
| CN-102245586-B | Thiadiazole-substituted arylamides | HOFFMANN LA ROCHE | 2014-07-09 | — | — | CN | disclosed |
| CN-101903355-B | Imidazole-substituted arylamides | HOFFMANN LA ROCHE | 2014-05-14 | — | — | CN | disclosed |
| CN-101903348-B | Pyrazole-substituted arylamides | HOFFMANN LA ROCHE | 2013-08-14 | — | — | CN | disclosed |
| CN-103159692-A | Tetrazole-substituted arylamides | HOFFMANN LA ROCHE | 2013-06-19 | — | — | CN | disclosed |
| CN-101903359-B | Triazole-substituted arylamide derivatives and their use as P2X3 and/or P2X2/3 purinergic receptor antagonists | HOFFMANN LA ROCHE | 2013-05-22 | — | — | CN | disclosed |
| CN-101479250-B | Tetrazole-substituted arylamides | HOFFMANN LA ROCHE | 2013-05-22 | — | — | CN | disclosed |
| CN-102574778-A | Novel biphenyl and phenyl-pyridine amides | HOFFMANN LA ROCHE | 2012-07-11 | — | — | CN | disclosed |
| CN-102438989-A | Novel oxazolone and pyrrolidinone-substituted arylamides | HOFFMANN LA ROCHE | 2012-05-02 | — | — | CN | disclosed |
| CN-102245586-A | Thiadiazole-substituted arylamides | HOFFMANN LA ROCHE | 2011-11-16 | — | — | CN | disclosed |
| CN-101903348-A | Novel pyrazole-substituted arylamides | HOFFMANN LA ROCHE | 2010-12-01 | — | — | CN | disclosed |
| CN-101903355-A | Novel imidazole-substituted arylamides | HOFFMANN LA ROCHE | 2010-12-01 | — | — | CN | disclosed |
| CN-101903359-A | Triazole-substituted arylamide derivatives and their use as P2X3And/or P2X2/3Use of purinergic receptor antagonists | HOFFMANN LA ROCHE | 2010-12-01 | — | — | CN | disclosed |
| CN-101479250-A | Tetrazole-substituted arylamides | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | disclosed |