Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 3/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27769424 | 0.86 | XDH (0.37) | XDHMAPK1CRHBPATMCRHR2 | |
| SCHEMBL27769423 | 0.80 | DGAT1 (0.51) | XDHDGAT1SOAT1MAPTL3MBTL1 | |
| SCHEMBL4487423 | 0.79 | DGAT1 (0.54) | DGAT1SOAT1 | |
| SCHEMBL14813133 | 0.79 | DGAT1 (0.54) | DGAT1SOAT1 | |
| SCHEMBL27790748 | 0.78 | DGAT1 (0.44) | XDHDGAT1SOAT1NOTUM | |
| SCHEMBL4463767 | 0.78 | DGAT1 (0.47) | XDHDGAT1SOAT1 | |
| SCHEMBL4569575 | 0.77 | NOTUM (0.36) | DGAT1NOTUM | |
| SCHEMBL4481074 | 0.76 | DGAT1 (0.44) | XDHDGAT1SOAT1 | |
| SCHEMBL4941289 | 0.74 | DGAT1 (0.58) | XDHPRCPDGAT1SOAT1 | |
| SCHEMBL2551085 | 0.72 | DGAT1 (0.69) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101636155-A | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme | ABBOTT LAB | 2010-01-27 | — | — | CN | claimed |
| CN-101636155-A | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme | ABBOTT LAB | 2010-01-27 | — | — | CN | disclosed |