Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPA | P38571 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27748291 | 0.77 | MAPK1 (0.36) | — | |
| SCHEMBL28778847 | 0.74 | NPC1 (0.32) | — | |
| SCHEMBL3928503 | 0.72 | LIPA (0.31) | LIPA | |
| SCHEMBL3928508 | 0.72 | PPARD (0.39) | — | |
| SCHEMBL27775943 | 0.71 | ALDH1A1 (0.32) | — | |
| SCHEMBL11035246 | 0.67 | FDPS (0.36) | — | |
| SCHEMBL28919178 | 0.67 | GSK3B (0.33) | — | |
| SCHEMBL10865172 | 0.66 | — | — | |
| SCHEMBL28606611 | 0.66 | — | — | |
| SCHEMBL13022683 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101484428-B | Alkyl-pyridazine derivatives as inhibitors of 11 beta hydroxysteroid dehydrogenase type 1(11b-HSD 1) | HOFFMANN LA ROCHE | 2011-11-16 | — | — | CN | disclosed |
| CN-101484428-A | Alkyl-pyridazine derivatives as inhibitors of 11 beta hydroxysteroid dehydrogenase type 1(11b-HSD 1) | HOFFMANN LA ROCHE (CH) | 2009-07-15 | — | — | CN | disclosed |