Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5373643 | 0.87 | CHRM2 (0.47) | POLBKEAP1NFE2L2CHRM3CHRM2 | |
| SCHEMBL27658104 | 0.85 | CHRM2 (0.46) | POLBKEAP1NFE2L2CHRM3CHRM2 | |
| Lithium Ion SCHEMBL27658106 | 0.84 | CHRM2 (0.45) | POLBKEAP1NFE2L2CHRM3CHRM2 | |
| SCHEMBL1610849 | 0.77 | KEAP1 (0.68) | POLBKEAP1NFE2L2CHRM3CHRM2 | |
| SCHEMBL27483674 | 0.77 | KEAP1 (0.68) | POLBKEAP1NFE2L2CHRM3CHRM2 | |
| SCHEMBL4741114 | 0.77 | KEAP1 (0.68) | POLBKEAP1NFE2L2CHRM3CHRM2 | |
| SCHEMBL1234889 | 0.75 | KEAP1 (0.70) | POLBKEAP1NFE2L2CHRM3CHRM2 | |
| SCHEMBL2655676 | 0.75 | CHRM3 (0.64) | KEAP1NFE2L2CHRM3CHRM2CHRM1 | |
| SCHEMBL4208886 | 0.75 | CHRM3 (0.64) | KEAP1NFE2L2CHRM3CHRM2CHRM1 | |
| SCHEMBL522945 | 0.75 | KEAP1 (0.70) | POLBKEAP1NFE2L2CHRM3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101878026-B | Pharmacological adjunctive therapy associated with glaucoma filtration surgery | BAUSCH & LOMB | 2013-11-20 | — | — | CN | disclosed |
| CN-101484187-B | Composition comprising dissociated glucocorticoid receptor agonist and immunosuppressant for treating dry eye | BAUSCH & LOMB INCORPROATED | 2012-12-26 | — | — | CN | disclosed |
| CN-101553214-B | Compositions and methods for treating, controlling, reducing, ameliorating, or preventing allergy | BAUSCH & LOMB INCORPROATED | 2012-12-26 | — | — | CN | disclosed |
| CN-101969950-A | Compositions comprising a dissociated glucocorticoid receptor agonist for treating or controlling anterior-segment inflammation | BAUSCH & LOMB | 2011-02-09 | — | — | CN | disclosed |
| CN-101878026-A | Pharmacological adjunctive therapy associated with glaucoma filtration surgery | BAUSCH & LOMB | 2010-11-03 | — | — | CN | disclosed |
| CN-101553214-A | Compositions and methods for treating, controlling, reducing, ameliorating, or preventing allergy | BAUSCH & LOMB (US) | 2009-10-07 | — | — | CN | disclosed |
| CN-101528208-A | Compositions and methods for treating or preventing glaucoma or its progression | BAUSCH & LOMB (US) | 2009-09-09 | — | — | CN | disclosed |
| CN-101522196-A | Treatment of infections and their sequelae with combined isolated glucocorticoid receptor agonists and anti-infective agents | BAUSCH & LOMB (US) | 2009-09-02 | — | — | CN | disclosed |
| CN-101522187-A | Compositions and methods for treating, reducing, ameliorating, or alleviating posterior-segment ophthalmic diseases | BAUSCH & LOMB (US) | 2009-09-02 | — | — | CN | disclosed |
| CN-101484187-A | Composition comprising dissociated glucocorticoid receptor agonist and immunosuppressant for treating dry eye | BAUCH & LOMB INC (US) | 2009-07-15 | — | — | CN | disclosed |